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Protective effect of vitamin A against oxidative stress caused by methotrexate
Other Title(s)
التأثير الوقائي لفيتامين أ ضد الجهد التأكسدي المتسبب عن الميثوتريكسيت
Joint Authors
al-Lami, Makarim Qasim Dawud
al-Mahdawi, Firyal Abd al-Munaf
Sayil, Asma' Ibrahim
al-Jalabi, Salah Mahdi Muhsin
Source
Issue
Vol. 54, Issue 3 (30 Sep. 2013), pp.585-589, 5 p.
Publisher
University of Baghdad College of Science
Publication Date
2013-09-30
Country of Publication
Iraq
No. of Pages
5
Main Subjects
Abstract AR
Methotrexate (MTX), a folate antagonist agent, is mainly used in treatment of malignant tumors and autoimmune diseases.
The present study was undertaken to determine whether antioxidant vitamin (vitamin A) could ameliorate methotrexate induced oxidative stress in male rabbits.
Twenty male rabbits were randomly assigned into four groups.
Group 1 : control group, Group 2 : MTX-treated group (received 20 mg / kg MTX intraperitoneally), Group 3 : Vit.A treated group received 5000 IU Vit.A orally) and Group 4 : MTX + Vit.A treated group received MTX 20 mg / kg plus 5000 IU vit.A).
After 4 weeks of treatment, blood samples were collected by cardiac puncture to determine the serum malondialdehyde (MDA), as a good indicator for lipid peroxidation and oxidative stress.
The results showed that there was a significant increase (p < 0.05) in serum MDA level in MTX-treated group compared with control group.
Also, the results revealed that there was a significant decrease (p < 0.05) in serum MDA level in MTX + Vit.A treated group in comparison with MTX-treated group.
The present study suggests that the administration of vit.A with MTX is associated with reduction in oxidative stress, and therapeutic role in reduced toxicity of MTX.
American Psychological Association (APA)
Sayil, Asma' Ibrahim& al-Mahdawi, Firyal Abd al-Munaf& al-Lami, Makarim Qasim Dawud& al-Jalabi, Salah Mahdi Muhsin. 2013. Protective effect of vitamin A against oxidative stress caused by methotrexate. Iraqi Journal of Science،Vol. 54, no. 3, pp.585-589.
https://search.emarefa.net/detail/BIM-341979
Modern Language Association (MLA)
al-Mahdawi, Firyal Abd al-Munaf…[et al.]. Protective effect of vitamin A against oxidative stress caused by methotrexate. Iraqi Journal of Science Vol. 54, no. 3 (2013), pp.585-589.
https://search.emarefa.net/detail/BIM-341979
American Medical Association (AMA)
Sayil, Asma' Ibrahim& al-Mahdawi, Firyal Abd al-Munaf& al-Lami, Makarim Qasim Dawud& al-Jalabi, Salah Mahdi Muhsin. Protective effect of vitamin A against oxidative stress caused by methotrexate. Iraqi Journal of Science. 2013. Vol. 54, no. 3, pp.585-589.
https://search.emarefa.net/detail/BIM-341979
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 588-589
Record ID
BIM-341979