Mismatched related hematopoietic stem cell transplantation
Joint Authors
Wahadnih, Adil M.
Bin Dahman, Haifa A.
Abu Shukiar, Muhammad E.
Ajarimah, Muhammad A.
Habbabah, Ziyad M.
Zayyud, Raid M.
Habshinah, Muin S.
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 24, Issue 6 (31 Dec. 2013), pp.1137-1143, 7 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2013-12-31
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Topics
Abstract EN
Hematopoietic stem cell transplantation (HSCT) is the definitive therapy for a variety of primary immunodeficiency syndromes (PIDs).
However, no more than 30% of the patients will have a human leukocyte antigen (HLA)-identical sibling.
We retrospectively analyzed our results of ten patients with PID; severe combined immunodeficiency (SCID) (n = 7), hyper IgM (HIgM) (n = 1) and combined immunodeficiency (CID) (n = 2), who lacked a fully matched donor and underwent mismatched related HSCT during the period from 2008 to 2010.
The median age at the time of transplantation ranged between 3 and 84 months (median 6.5 months).
Peripheral blood stem cells (PBSC) were used in all HSCTs.
The mean value of the peripheral CD34+ cells infused was 9.19 × 106 / kg recipient weight.
Patients received different conditioning protocols.
All patients received anti-graft versus host disease (GVHD) prophylaxis and all were engrafted.
Mixed chimeras (5–55 %) was noticed.
GVHD was observed in 50% of the patients Post-transplant follow-up ranged from 3 weeks to 36 months (median 15 months).
Five patients are still alive while one patient developed engraftment syndrome followed by graft slippage for which a second transplant with CD34+ stem cells 5.8 × 106 / kg recipient’s weight was infused.
The others died from sepsis and transplant-related complications.
Immune reconstitution was noticed in four patients.
In conclusion, HLA-haploidentical stem cell transplantation may be feasible, with appropriate GVHD prophylaxis, for patients with PID who lack a fully matched donor.
American Psychological Association (APA)
Wahadnih, Adil M.& Bin Dahman, Haifa A.& Abu Shukiar, Muhammad E.& Habbabah, Ziyad M.& Ajarimah, Muhammad A.& Zayyud, Raid M.…[et al.]. 2013. Mismatched related hematopoietic stem cell transplantation. Saudi Journal of Kidney Diseases and Transplantation،Vol. 24, no. 6, pp.1137-1143.
https://search.emarefa.net/detail/BIM-342456
Modern Language Association (MLA)
Wahadnih, Adil M.…[et al.]. Mismatched related hematopoietic stem cell transplantation. Saudi Journal of Kidney Diseases and Transplantation Vol. 24, no. 6 (2013), pp.1137-1143.
https://search.emarefa.net/detail/BIM-342456
American Medical Association (AMA)
Wahadnih, Adil M.& Bin Dahman, Haifa A.& Abu Shukiar, Muhammad E.& Habbabah, Ziyad M.& Ajarimah, Muhammad A.& Zayyud, Raid M.…[et al.]. Mismatched related hematopoietic stem cell transplantation. Saudi Journal of Kidney Diseases and Transplantation. 2013. Vol. 24, no. 6, pp.1137-1143.
https://search.emarefa.net/detail/BIM-342456
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1142-1143
Record ID
BIM-342456