Predictors of early post-operative hypocalcemia after parathyroidectomy for secondary hyperparathyroidism

Abstract EN

We sought to identify predictors of development of early post-operative hypocalcemia after parathyroidectomy for secondary hyperparathyroidism.

The patients were divided into two groups according to their serum calcium (Ca) levels within 24 hours of undergoing parathyroidectomy : the hypocalcemia group (22 patients) with post-operative serum Ca levels of 2 mmol / L or less, and the normocalcemia group (48 patients), with post-operative serum Ca levels higher than 2 mmol / L.

By using multivariate stepwise logistic regression analysis, high pre-operative serum Ca level had the strongest predictive value of development of early hypocalcaemia with an adjusted odds ratio (aOR) of 3.01, followed by hypo-albuminemia (aOR = 2.72), younger age (aOR = 2.56), and high pre-operative alkaline phosphatase (ALP) levels (aOR = 2.28).

We conclude that among patients with secondary hyperparathyroidism, age, levels of pre-operative serum Ca, ALP and albumin correlate positively with the development of early post-operative hypocalcemia Patients with one.