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Effects of oral enalapril and verapamil on dialysis adequacy and solute clearance in chronic ambulatory peritoneal dialysis
Joint Authors
Abolghasemi, Rozita
Zangneh, Hooman Farhang
Rahmani, Layla
Argani, Hasan
Atabak, Shahnaz
Taziki, Omolbanin
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 24, Issue 6 (31 Dec. 2013), pp.1170-1174, 5 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2013-12-31
Country of Publication
Saudi Arabia
No. of Pages
5
Main Subjects
Topics
Abstract EN
Peritoneal dialysis offers several advantages such as better clearance of intermediate large molecules and better preservation of renal residual function when compared with hemodialysis.
However, dialysis adequacy is one of the subjects of concern of this modality.
There are some drugs that are capable of influencing solute transport in the peritoneum, such as acetyle co-enzyme inhibitors (ACE-I) medications and calcium channel blockers.
Captopril and Verapamil are often mentioned, but their use has shown varying conclusions and initial studies were performed with the intra-peritoneal administration of these drugs and there are only a few studies on the effect of the oral administration of these drugs.
This study was undertaken with the aim to evaluate the effects of oral administration of Verapamil and Enalapril among continuous ambulatory peritoneal dialysis (CAPD) patients.
The results of this study showed that Verapamil and Enalapril do not have any effects on glucose, creatinine, sodium, potassium and urea clearance (during the 4-h peritoneal equilibration test (PET) test).
However, it was shown that Enalapril significantly increased the peritoneal urea Kt / V and caused a meaningful decrease in the diastolic and mean blood pressures.
Therefore, we feel that Enalapril may be administered as an anti-hypertensive medication of choice in CAPD patients, which can also result in better dialysis adequacy.
However, further studies with larger sample sizes are needed in the future.
American Psychological Association (APA)
Atabak, Shahnaz& Taziki, Omolbanin& Argani, Hasan& Abolghasemi, Rozita& Zangneh, Hooman Farhang& Rahmani, Layla. 2013. Effects of oral enalapril and verapamil on dialysis adequacy and solute clearance in chronic ambulatory peritoneal dialysis. Saudi Journal of Kidney Diseases and Transplantation،Vol. 24, no. 6, pp.1170-1174.
https://search.emarefa.net/detail/BIM-342582
Modern Language Association (MLA)
Rahmani, Layla…[et al.]. Effects of oral enalapril and verapamil on dialysis adequacy and solute clearance in chronic ambulatory peritoneal dialysis. Saudi Journal of Kidney Diseases and Transplantation Vol. 24, no. 6 (2013), pp.1170-1174.
https://search.emarefa.net/detail/BIM-342582
American Medical Association (AMA)
Atabak, Shahnaz& Taziki, Omolbanin& Argani, Hasan& Abolghasemi, Rozita& Zangneh, Hooman Farhang& Rahmani, Layla. Effects of oral enalapril and verapamil on dialysis adequacy and solute clearance in chronic ambulatory peritoneal dialysis. Saudi Journal of Kidney Diseases and Transplantation. 2013. Vol. 24, no. 6, pp.1170-1174.
https://search.emarefa.net/detail/BIM-342582
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1174
Record ID
BIM-342582