Pauci-immune crescentic glomerulonephritis in the down’s syndrome
Joint Authors
Bin Maiz, Hedi
Abd al-Rahim, Izz al-Din
Hedri, Hafiz
Sharif, Mijda
Ounissi, Mundhir
Gergah, Tahir
Goucha, Rim
Khidr, Adil
Barbush, Samiyah
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 24, Issue 6 (31 Dec. 2013), pp.1223-1227, 5 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2013-12-31
Country of Publication
Saudi Arabia
No. of Pages
5
Main Subjects
Topics
- Patients
- Case studies
- Kidneys
- Diseases
- Mental deficiency
- Complications(Medicine)
- Glomerulonephritis
- Down syndrome
Abstract EN
Kidney disease is a rare complication in patients with the Down’s syndrome.
However, with increased survival, it appears that a growing number of these patients present with glomerulonephritis.
Most cases have been reported as case reports and include lesions such as mesangiocapillary glomerulonephritis with hypo-complementemia, crescentic glomerulonephritis with anti-neutrophil cytoplasmic antibodies (ANCA), amyloidosis and immunotactoid glomerulopathy.
We report the observation of a 38-year-old man with the Down’s syndrome who presented with severe renal failure, proteinuria and microscopic hematuria evolving over two months.
There was no history of congenital heart disease or urinary symptoms.
Percutaneous renal biopsy revealed fibrous crescents, rupture of Bowman’s capsule and peri-glomerular granuloma ; there were no deposits on immunofluorescence study.
Thoracic computerized tomography scan showed alveolar congestion.
The patient tested negative for ANCA.
At the time of reporting, the patient is on regular chronic hemodialysis.
Our case illustrates a distinct entity that further expands the spectrum of renal disease known to occur in the Down’s syndrome.
Early detection of the renal disorders may prevent or slow down the progression.
American Psychological Association (APA)
Sharif, Mijda& Hedri, Hafiz& Ounissi, Mundhir& Gergah, Tahir& Goucha, Rim& Abd al-Rahim, Izz al-Din…[et al.]. 2013. Pauci-immune crescentic glomerulonephritis in the down’s syndrome. Saudi Journal of Kidney Diseases and Transplantation،Vol. 24, no. 6, pp.1223-1227.
https://search.emarefa.net/detail/BIM-342689
Modern Language Association (MLA)
Sharif, Mijda…[et al.]. Pauci-immune crescentic glomerulonephritis in the down’s syndrome. Saudi Journal of Kidney Diseases and Transplantation Vol. 24, no. 6 (2013), pp.1223-1227.
https://search.emarefa.net/detail/BIM-342689
American Medical Association (AMA)
Sharif, Mijda& Hedri, Hafiz& Ounissi, Mundhir& Gergah, Tahir& Goucha, Rim& Abd al-Rahim, Izz al-Din…[et al.]. Pauci-immune crescentic glomerulonephritis in the down’s syndrome. Saudi Journal of Kidney Diseases and Transplantation. 2013. Vol. 24, no. 6, pp.1223-1227.
https://search.emarefa.net/detail/BIM-342689
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1226-1227
Record ID
BIM-342689