Immunological aspects of biopsy-proven lupus nephritis in Bahraini patients with systemic lupus erythematosus
Joint Authors
Hasan, Adil B.
Aba al-Khayl, Ali A.
al-Agroudy, Amjad E.
al-Arid, Samir M.
al-Gharib, Sumayyah M.
Farid, Iman
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 24, Issue 6 (31 Dec. 2013), pp.1271-1279, 9 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2013-12-31
Country of Publication
Saudi Arabia
No. of Pages
9
Main Subjects
Topics
Abstract EN
Lupus nephritis (LN) is a frequent and potentially serious complication of systemic lupus erythematosus (SLE) that may influence morbidity and mortality.
Immunological investigations are aiding tools to the kidney biopsy findings in early diagnosis, in addition to monitoring the effect of therapy.
The aim of the present study is to highlight the role of these investigations in a group of Bahraini patients and to determine whether there is any positive association between these findings and the outcome of LN.
The current study is a retrospective case–control study of randomly selected 88 SLE patients, 44 with biopsyproven LN and 44 without, acting as controls.
All renal biopsies performed during the period from 1996 to 2012 were classified according to the World Health Organization classification.
Immunological investigations analyzed are: Antinuclear antibodies (ANA), anti-ds DNA, anti-ENA, anti-cardiolipin antibodies (abs) and complement components C3, C4.
Human leukocyte antigen (HLA) typing class II was performed on selected cases.
All patients had positive ANA (100 %).
A significantly high frequency of anti-Smith abs among the non-LN group (43.18 %) compared with the LN group (18.18 %) was found (P < 0.001).
On the other hand, the anti-Ro / SSA abs in the non-LN group was also found at a statistically higher frequency (20.45 %) compared with that in the LN group (4.54 %) (P < 0.01).
Anti-ds-DNA abs were found to be higher in the LN group (84.09 %) compared with the non-LN group (70.45 %), but the difference was not statistically significant (P = 0.083) There was a positive association of ANA positivity and low C3 and or C4 in the studied group.
In our study, 88.2 % of the HLA typed patients had HLADR2, DR3 or both.
In conclusion, in our Arabic Bahraini SLE patients, the presence of anti-Smith, anti-Ro / SSA and anti-RNP antibodies and the absence of antids DNA antibodies are independent predictive markers for renal involvement.
However, more prospective studies with a larger number of patients are essential to ascertain those findings.
American Psychological Association (APA)
Farid, Iman& Hasan, Adil B.& Aba al-Khayl, Ali A.& al-Agroudy, Amjad E.& al-Arid, Samir M.& al-Gharib, Sumayyah M.. 2013. Immunological aspects of biopsy-proven lupus nephritis in Bahraini patients with systemic lupus erythematosus. Saudi Journal of Kidney Diseases and Transplantation،Vol. 24, no. 6, pp.1271-1279.
https://search.emarefa.net/detail/BIM-342742
Modern Language Association (MLA)
Hasan, Adil B.…[et al.]. Immunological aspects of biopsy-proven lupus nephritis in Bahraini patients with systemic lupus erythematosus. Saudi Journal of Kidney Diseases and Transplantation Vol. 24, no. 6 (2013), pp.1271-1279.
https://search.emarefa.net/detail/BIM-342742
American Medical Association (AMA)
Farid, Iman& Hasan, Adil B.& Aba al-Khayl, Ali A.& al-Agroudy, Amjad E.& al-Arid, Samir M.& al-Gharib, Sumayyah M.. Immunological aspects of biopsy-proven lupus nephritis in Bahraini patients with systemic lupus erythematosus. Saudi Journal of Kidney Diseases and Transplantation. 2013. Vol. 24, no. 6, pp.1271-1279.
https://search.emarefa.net/detail/BIM-342742
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1277-1279
Record ID
BIM-342742