Assessment of renal function in type 2 diabetic patients by measurement of serum cystatin C in al-Hilla City

Abstract EN

This study was intended to evaluate the performance of serum cystatin C and its equations for the estimation of glomerular filteration rate in comparison with serum creatinine and its equations.

A total of 62 diabetic patients and 21 apparently healthy subjects as a control group were assessed.

The tests done were; urine analysis, serum cystatin C, serum creatinine, HbA1c, and serum glucose.

The weight, height and blood pressure were measured for all subjects.

The results of this study showed a significant differences in the serum cystatin C level of the patients group (1.11 ± 0.25mg / l, p < 0.01) as compared with its level in the controls group (0.76 ± 0.08 mg / l, P < 0.01).

Similarly there were a significant differences in the serum levels of glucose (224 ± 61.9 mg / dl), HbA1c (9.6 ± 2.1 %) and creatinine (1.01 ± 0.31mg / dl) (p < 0.01) of the patients group as compared with that of controls group : (106.57 ± 19.17mg / dl), (6.13 % ± 2.7 %), (0.76 ± 0.66mg / dl) (p < 0.01)respectively.

There were a very strong negative correlations in the patients group between serum cystatin C and estimated GFRcyst + creat (r = -0.929, p < 0.01), while the results for serum creatinine were : (r = -0.798 p < 0.01).

The results of this study showed superiority of serum cystatin C and its equations over serum creatinine and its equations in detecting early decline in GFR.