Estrogen and progesterone receptors overexpression in breast carcinoma and their correlation with ages of patients, histopathological types and grades of tumors

Abstract EN

Background Carcinoma of the breast is one of the most important diseases for women, in the world.

The disease is the commonest cause of death among women aged 40-50.

Breast carcinoma is uncommon in women younger than age 30, thereafter, the risk steadily increases throughout life, but after menopause the upward slop of the curve almost plateaus.

The incidence of breast carcinoma is increasing in all industrialized countries, changes in diet, reproductive patterns and altered exposure to endogenous and exogenous substances with hormonal activity have been suggested as contributing to this increase.

Aim of the study : to assess estrogen and progesterone receptor over expression in breast carcinoma and its correlation with ages of patients, histopathological types & grades of tumors.

Materials and methods : this study was included 58 paraffin embedded samples from female patients with breast carcinoma were collected randomly from period of June2010- November 2012 in AL-Hilla Teaching hospital.

The clinical information were collected including ages of the patients, histopathological types, & tumor grades from clinical reports of the hospital.

A manual avidin biotin peroxidase complex procedure (ABC) system was used in the imunohistochemical analysis (Dako Cytomation Copenhagen, Denmark).

Results : the estrogen, progesterone receptors determined by immunohistochemical method revealed ER+ / PR+ in 15.5 % of cases, ER+ / PR- in 3.4 %, ER-/ PR+ in 29.3 and ER- / PR- in 51 % of cases , all ER+ / PR+ are of invasive ductal carcinoma, most cases with ER+ / PR+ are of premenapuasal and perimenapuasal age group 36.2 % & 32.7 % respectively and most cases with grade III are ER- / PR Conclusion : present study reported high percentage of ER- / PR- cases of breast ca ,all ER+ / PR+ cases are of invasive ductal ca, the population of high grade IDC were predominantly ER- / PR.