Study the spermatozoal lipid peroxidation and creatine kinase activity on sperm parameters after use of simvastatin in infertile male patients

Abstract EN

The present study was carried out on a total of 55 patient with primary male factor infertility in Maternity and Childhood Teaching Hospital and Cancer Research Center, Kufa Medical College in Najaf Province between April 2005-June 2006.

The distribution of 55 patients in group I was classified into 8 subgroups according to the pathological cause of infertility and 35 normal proven fertility volunteer men served as a control group.

All patient group was given simvastatin (simlo) tablets lpca, lpca laboratories Ltd Mubai : India at dose 20 mg twice per day for a period of 3 months.

Spermatozoal malondialdehyde and creatine kinase (CK) were assessed before and after termination of treatment period.

The present results showed a statistically significant decrease (p < 0.05) in malondialdehyde MDA level and creatine kinase CK activity.

Data also pointed out that there was a positive relation between spermatozoal MDA level and CK activity in most Simvastatin treated sperm pathological subgroups.

This study might suggest and adopt an evidence of the action of simvastatin in lowering lipid peroxidation as MDA level and CK activity as an indicator of sperm parameters improvement due to antioxidant properties in patients with spermatozoal oxidative stress.