Alpha-1 antitrypsin deficiency in Iranian patients with chronic obstructive pulmonary disease
Joint Authors
Jowkar, Zahrah
Karami, Layla
Masoumpour, Masoum
Mihrabi, Samrad
Ghayoumi, Muhammad Ali
Gerami zadah, Bita
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 15, Issue 11 (30 Nov. 2013)8 p.
Publisher
Publication Date
2013-11-30
Country of Publication
United Arab Emirates
No. of Pages
8
Main Subjects
Topics
Abstract EN
Background : Alpha-1 antitrypsin deficiency is a genetic disease which affects both lung and liver.
This disease is a recognized factor for chronic obstructive pulmonary disease (COPD).
However its importance as the cause of COPD in a country such as Iran is unclear.
Objectives: This study was conducted to find out the role of α-1 antitrypsin deficiency as a cause of COPD in Iranian patients.
Materials and Methods : The serum concentration of α-1 antitrypsin was determined and the genotype of α-1 antitrypsin was also evaluated by PCR-RFLP in 130 patients with COPD and 50 normal healthy blood donors.
Results : No α-1 antitrypsin deficient case was found in normal healthy people and COPD patients.
Conclusions : Our results clarify that deficiency of α-antitrypsin is not a major cause of COPD in Iranian patients.
American Psychological Association (APA)
Gerami zadah, Bita& Jowkar, Zahrah& Karami, Layla& Masoumpour, Masoum& Mihrabi, Samrad& Ghayoumi, Muhammad Ali. 2013. Alpha-1 antitrypsin deficiency in Iranian patients with chronic obstructive pulmonary disease. Iranian Red Crescent Medical Journal،Vol. 15, no. 11.
https://search.emarefa.net/detail/BIM-343082
Modern Language Association (MLA)
Gerami zadah, Bita…[et al.]. Alpha-1 antitrypsin deficiency in Iranian patients with chronic obstructive pulmonary disease. Iranian Red Crescent Medical Journal Vol. 15, no. 11 (2013).
https://search.emarefa.net/detail/BIM-343082
American Medical Association (AMA)
Gerami zadah, Bita& Jowkar, Zahrah& Karami, Layla& Masoumpour, Masoum& Mihrabi, Samrad& Ghayoumi, Muhammad Ali. Alpha-1 antitrypsin deficiency in Iranian patients with chronic obstructive pulmonary disease. Iranian Red Crescent Medical Journal. 2013. Vol. 15, no. 11.
https://search.emarefa.net/detail/BIM-343082
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-343082