Cytotoxic properties of some medicinal plant extracts from Mazandaran, Iran

Abstract EN

Background : It was shown that plants derived agents are being used for treatment of cancer.

In this study, crude ethanolic extract of Consolida orientalis L., Ferula assa-foetida L., Coronilla varia L., Orobanche orientalis G.

Beck were screened in vitro for cytotoxic activity on Hela (Human cervical carcinoma) cell line.

Objectives : We performed the present study to evaluate the in vitro cytotoxic activity of four plant extracts that we gathered from north of Iran, Mazandaran Materials and Methods : Hela cells were treated with various concentrations of individual samples (0.0312, 0.0625, 0.125, 0.25, 0.5, 1, 2.5, 5, 7.5 and 10 mg/ml) for 72 hours.

Cell proliferation measured by MTT assay.

Results : Result from the performed assay showed that ethanolic extract of Consolida orientalis L., Ferula assa-foetida L., Coronilla varia L.

has more significant cytotoxicity effect on Hela cell line than Orobanche orientalis G.

Beck.

Conclusions : Extracts of the Consolida orientalis L., Ferula assa-foetida L., Coronilla varia L.

could be considered as potential sources of anticancer compounds but further studies are necessary for isolation and identification of biologically active substances.