Protective effect of silymarin on noise-induced hearing loss in guinea pigs
Joint Authors
Pourbakht, Akram
Muhammadkhani, Qasim
Khanavi, Mahnaz
Faghihzadeh, Soghrat
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 15, Issue 11 (30 Nov. 2013)13 p.
Publisher
Publication Date
2013-11-30
Country of Publication
United Arab Emirates
No. of Pages
13
Main Subjects
Topics
Abstract EN
Hearing capability plays a principal role on human's communication.
Noise-induced hearing loss (NIHL) caused by exposure to high noise levels is a serious socio-economic problem in modern societies.
NIHL can either be reversible, resulting in a temporary threshold shifts (TTS) or irreversible, resulting in a permanent threshold shifts (PTS).
PTS is often confirmed in the time span of between 2-6 weeks.
NIHL may be prevented by avoidance of excessive amounts of noise or reducing the sound energy entering the inner ear using hearing protective devices.
However, there are some conditions that such prevention is not possible such as noise exceeding the protective capabilities of the hearing protection device, working in military or the person does not tolerate the protection device.
Thus the protective agent for preventing NIHL would be useful.
Objective : Free radical molecules and consequence oxidative stress have been shown to play a significant role in noise-induced hearing loss.
Silymarin is an antioxidant flavonoid complex derived from the herb milk thistle has ability to mitigating the oxidative stress, scavenge free radicals.
In the current study, we aimed to evaluate the protective effect of silymarin on noise induced hearing loss in guinea pig by auditory brain stem response.
Material and Methods : Twenty guinea pigs randomly divided into 2 groups.
The animals in the experimental group were intraperitoneally injected with 100 mg / kg / day silymarin dissolved in propylene glycol for 6 consecutive days.
The control subjects were intraperitoneally injected with propylene glycol for 6 consecutive days.
All animals were exposed to 4 kHz octave band noise at 120dBSPL for 6 hours.
Auditory brainstem responses (ABRs) at frequencies of 2, 4, 6, 8, 12, 16 and 20 kHz were precisely recorded before intervention and then on intervals of 0, 3, 10 and 15 days after noise exposure.
Data were analyzed using repeated measures ANOVA.
Results : Threshold shifts for the experimental group at all frequencies immediately, 3, 10 and 15 days after noise exposure were significantly reduced compared to the control group (P < 0.01).
Conclusion : The findings indicate a protective effect of silymarin on temporary and permanent noise-induced hearing loss.
American Psychological Association (APA)
Muhammadkhani, Qasim& Pourbakht, Akram& Khanavi, Mahnaz& Faghihzadeh, Soghrat. 2013. Protective effect of silymarin on noise-induced hearing loss in guinea pigs. Iranian Red Crescent Medical Journal،Vol. 15, no. 11.
https://search.emarefa.net/detail/BIM-343112
Modern Language Association (MLA)
Muhammadkhani, Qasim…[et al.]. Protective effect of silymarin on noise-induced hearing loss in guinea pigs. Iranian Red Crescent Medical Journal Vol. 15, no. 11 (2013).
https://search.emarefa.net/detail/BIM-343112
American Medical Association (AMA)
Muhammadkhani, Qasim& Pourbakht, Akram& Khanavi, Mahnaz& Faghihzadeh, Soghrat. Protective effect of silymarin on noise-induced hearing loss in guinea pigs. Iranian Red Crescent Medical Journal. 2013. Vol. 15, no. 11.
https://search.emarefa.net/detail/BIM-343112
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-343112