A randomized controlled trial on analgesic effects of intravenous acetaminophen versus dexamethasone after pediatric tonsillectomy
Joint Authors
Fayiz, Sayyid Hamid Rida
Rahimzadeh, Poupak
Alebouyeh, Mahmud Rida
Sedaghat, Minow
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 15, Issue 11 (30 Nov. 2013)15 p.
Publisher
Publication Date
2013-11-30
Country of Publication
United Arab Emirates
No. of Pages
15
Main Subjects
Topics
Abstract EN
Background : A few studies are available actually comparing the clinical efficacy of intravenous acetaminophen with other medications such as dexamethasone to inhibit postoperative adverse events in children.
Objectives : This randomized blinded controlled trial was designed to compare controlling status of postoperative events in children after tonsillectomy randomized to receive either intravenous acetaminophen or dexamethasone.
Materials / Patients and Methods: Eighty four children aged between 4 to 13 undergoing tonsillectomy were randomized using a computer-generated schedule to double-blind treatment with intravenous acetaminophen (15 mg / kg) or intravenous dexamethasone (0.1 mg / kg).
Children were post-operatively assessed for swallowing pain, pain while opening mouth, ear pain, and postoperative sore throat in recovery room (within one hour after surgery), at the time of admission to the ward, as well as at 12 and 24 hours after surgery, assessed by the objective pain scoring system (OPS ; minimum score: 0 = no pain, maximum score : 10 = extreme pain).
Results : There were no significant differences between the two groups with regard to the severity of postoperative pain due to swallowing or opening mouth measured at the different study time points from postoperative recovery to 24 hours after the surgery.
There was no difference in ear pain severity at the time of postoperative recovery, at the admission time to ward and also at 12 hours after surgery; however mean score of ear pain severity was significantly higher in those who administered acetaminophen 24 hours after operation.
Also, the mean score severity of sore throat was significantly higher in the acetaminophen compared with the dexamethasone group within 12 hours of surgery.
Postoperative vomiting and bleeding were similarly observed between the two study groups.
The severity of swallowing pain, pain while opening mouth, ear pain, as well as postoperative sore throat as gradually assuaged within 24 hours of tonsillectomy in both groups, however no between-group differences were observed in the trend of the severity of these events.
Conclusions : The dexamethasone-based regimen may have more advantage over the intravenous acetaminophen regimen for inhibiting pain and PONV following tonsillectomy in children.
American Psychological Association (APA)
Fayiz, Sayyid Hamid Rida& Rahimzadeh, Poupak& Alebouyeh, Mahmud Rida& Sedaghat, Minow. 2013. A randomized controlled trial on analgesic effects of intravenous acetaminophen versus dexamethasone after pediatric tonsillectomy. Iranian Red Crescent Medical Journal،Vol. 15, no. 11.
https://search.emarefa.net/detail/BIM-343124
Modern Language Association (MLA)
Fayiz, Sayyid Hamid Rida…[et al.]. A randomized controlled trial on analgesic effects of intravenous acetaminophen versus dexamethasone after pediatric tonsillectomy. Iranian Red Crescent Medical Journal Vol. 15, no. 11 (2013).
https://search.emarefa.net/detail/BIM-343124
American Medical Association (AMA)
Fayiz, Sayyid Hamid Rida& Rahimzadeh, Poupak& Alebouyeh, Mahmud Rida& Sedaghat, Minow. A randomized controlled trial on analgesic effects of intravenous acetaminophen versus dexamethasone after pediatric tonsillectomy. Iranian Red Crescent Medical Journal. 2013. Vol. 15, no. 11.
https://search.emarefa.net/detail/BIM-343124
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-343124