Glioblastoma multiform : analysis of patients treated with radiotherapy at King Abdulaziz University Hospital

Abstract EN

Treatment of Glioblastoma Multiform typically involves maximal surgical resection, followed by adjuvant radiation therapy.

In this study, all patients with GBM treated with radiation therapy after initial surgical intervention at King Abdulaziz University Hospital were reviewed.

From April, 2000 to December 2002, 13 patients were treated, 9 (69%) males and 4 (31%) females.

Two (15%) patients had near complete resection, one (8%) had biopsy only and 10 (77%) had partial resection.

Radiation therapy was given on palliative intent in 10 (77%) patients with dose of 24-30 Gy, and 3 (23%) cases treated radically with dose of 54-60 Gy.

Radiological follow-up after 6-8 weeks from completion of radiation therapy showed complete response in 8%, partial response in 38%, stable disease in 8%, disease progression in 38% and 8% did not have their radiologic evaluation.

Evaluation after one year showed overall survival rate was 36%, the median survival time was 9.5 months; the median time to disease progression was 6 months.

Radiation therapy provided good palliation for these patients.