Synthesis of certain new dibenz [c, e] azepine-5, 7-diones of expected antihyperlipidemic activity

Abstract EN

The structural requirements for decreasing cholesterol and triglyceride levels remain largely uninvestigated.

Thus a systematic investigation of certain N-substituted dibenz[c,e]azepines is necessary.

Twenty-four compounds of certain new N-substituted derivatives of dibenz[c,e]azepines-5,7-diones were synthesized and tested for their anticholestesrolemic and antitriglyceridimic activities.

The evaluation of antihyperlipidemic activity of dibenz[c,e]azepine-5,7-diones (VII, X-XII) against Triton-WR1339-induced hyperlipidemia in rats showed a significant lowering of serum total cholesterol and triglyceride levels at a dose of 150 mg/kg compared with the control value.

The phenyl substituted derivatives of diphenimide have shown a pronounced decrease in both triglyceride and cholesterol levels.