Evaluation of immunomodulatory effects of antiepileptic drug phenytoin
Joint Authors
al-Fararjah, Muhammad A.
Jabir, Muhammad H.
Abd al-Rahman, Yasin S.
Source
Jordan Journal of Biological Sciences
Issue
Vol. 6, Issue 4 (31 Dec. 2013), pp.328-333, 6 p.
Publisher
The Hashemite University Deanship of Academic Research and Graduate
Publication Date
2013-12-31
Country of Publication
Jordan
No. of Pages
6
Main Subjects
Topics
Abstract EN
The immunomodulatory effects of phenytoin (PHN), used as an antiepileptic agent were investigated in vivo using female Balb / c mice.
The main aim of this study was to investigate the immunotoxicity of PHN.
Animals were divided into six groups, eight animals per group.
Group I, served as a control group, received only the vehicle.
Groups (II-VI) were received a daily intraperitoneal dose of PHN (2.5, 5, 10, 15 and 25 mg / kg, respectively) over a period of 21 days.
PHN has shown a significant decrease in the animal body weight.
The relative weights of animal's spleens were also decreased significantly at doses of (10, 15, and 25 mg / kg).
PHN showed a significant decrease in the percentage of circulating neutrophils and lymphocytes and an increase in the percentage of circulating eosinophils.
The result showed a marked suppression in antibody production capacity as a humoral immune response and a suppression in the Delayed type hypersensitivity response as a cell mediated immune response in PHN-treated mice compared to the control group.
Detectable changes have also been noticed in the histology of the footpad tissue and spleen.
American Psychological Association (APA)
al-Fararjah, Muhammad A.& Jabir, Muhammad H.& Abd al-Rahman, Yasin S.. 2013. Evaluation of immunomodulatory effects of antiepileptic drug phenytoin. Jordan Journal of Biological Sciences،Vol. 6, no. 4, pp.328-333.
https://search.emarefa.net/detail/BIM-344667
Modern Language Association (MLA)
al-Fararjah, Muhammad A.…[et al.]. Evaluation of immunomodulatory effects of antiepileptic drug phenytoin. Jordan Journal of Biological Sciences Vol. 6, no. 4 (Dec. 2013), pp.328-333.
https://search.emarefa.net/detail/BIM-344667
American Medical Association (AMA)
al-Fararjah, Muhammad A.& Jabir, Muhammad H.& Abd al-Rahman, Yasin S.. Evaluation of immunomodulatory effects of antiepileptic drug phenytoin. Jordan Journal of Biological Sciences. 2013. Vol. 6, no. 4, pp.328-333.
https://search.emarefa.net/detail/BIM-344667
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 333
Record ID
BIM-344667