The effects of organophosphorus insecticides on liver of male mice

Abstract EN

Background : pesticides cause ecological problems which may result in immediate mass mortality and biological magnifications.Objectives : to study the effect of organophosphorus on liver of male mice.

Material and Methods : Male Balb / c mice weighing 30-35 gm, 60 days old, were treated orally with monocrotophos(1 / 3 LD50, 1.8 mg / kg bw) and methyl parathion (1 / 3 LD50 ,2.8 mg / kg bw) for 30 days.

The liver weight, and aminotransferase, acid phosphatase and alkaline phosphatase in homogenates were estimated.

Results : the present study revealed the levels of acid phosphatase, alkaline phosphatase, aspartate aminotransferases and alanine aminotransferases, were significantly (p < 0.05) increased in liver with all of the two organophosphates.

Conclusion : it has been concluded that (monocrotophos and methyl parathion) caused increased in the levels of phosphatase and Aminotransferase as well as decreased in liver weight.