Construction of new ion selective electrodes for determination Fe (III)‎ and their application in pharmaceutical samples

Abstract EN

Liquid membrane electrodes for the determination iron (III) were constructed based on chloramphenicol sodium succinate and iron (III) CPSS-Fe (III) as ion pair complex, with four plasticizers Di-butyl phosphate (DBP) ; Di-butyl phthalate (DBPH) ; Di-octyl phthalate (DOP); Tri-butyl phosphate (TBP); in PVC matrix.

These electrodes give Nernstian and sub-Nernstian slopes (19.79, 24.60, 16.01 and 13.82mV / decade) and linear ranges from (1 x 10-5-1 x 10-2 M, 1 x 10-5-1 x 10-2 M, 1 x 10-6-1 x 10-2 M and 1 x 10-5-1 x 10-2 M) respectively.

The best electrode was based on DBP plasticizer which gave a slope 19.79 mV / decade, correlation coefficient 0.9999, detection limit of 9 × 10-6 M, lifetime 37 day displayed good stability and reproducibility and used to determine iron(III) in pharmaceutical samples.

The selectivity coefficient interferences of (K+, Na+, Cu+2, Mn+2, Zn2+, Al3+,Folic acid) were studied using separate and mixed methods for selectivity coefficient determination.

The pH and life time of the electrodes were also studied.