Role of statins in the treatment of chronic hepatitis C virus infection
Joint Authors
Abd al-Dayim, Ashraf A.
Badr, Jamal A.
al-Dahshan, Tariq
Azmi, Muhammad K.
Ahmad, Yusuf K.
Husayn, Musa A.
Source
Journal of the Egyptian Society of Parasitology
Issue
Vol. 42, Issue 3 (31 Dec. 2012), pp.535-540, 6 p.
Publisher
The Egyptian Society of Parasitology
Publication Date
2012-12-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Topics
Abstract EN
This study assessed the clinical outcome of fluvastatin in addition to the standard regimen used now for treatment of chronic HCV in Egypt.
A total of 80 patients with chronic hepatitis C virus infection fulfilled clinical, laboratory and histo-pathological criteria were ready for interferon therapy.
They were divided into two groups : GI (N = 40) received standard treatment for HCV Pegylated interferon and Ribavirin) and GII (N = 40) received standard treatment plus Fluvastatin (80 mg / daily).
Six months before and after treatment liver function tests and HCV-RNA were evaluated.
The results showed that addition of Fluvastatin to the standard HCV treatment (Pegylated interferon and Ribavirin) significantly increased sustained virological response (SVR) from (55 %-62.5 % ; P < 0.01) and significantly decreased viral load in relapse patients (P < 0.001).
No significant differences and correlations were found between serum levels of LDL-cholesterol and viral load before and after treatment in both groups.
American Psychological Association (APA)
Abd al-Dayim, Ashraf A.& Azmi, Muhammad K.& Ahmad, Yusuf K.& Badr, Jamal A.& Husayn, Musa A.& al-Dahshan, Tariq. 2012. Role of statins in the treatment of chronic hepatitis C virus infection. Journal of the Egyptian Society of Parasitology،Vol. 42, no. 3, pp.535-540.
https://search.emarefa.net/detail/BIM-347092
Modern Language Association (MLA)
Abd al-Dayim, Ashraf A.…[et al.]. Role of statins in the treatment of chronic hepatitis C virus infection. Journal of the Egyptian Society of Parasitology Vol. 42, no. 3 (Dec. 2012), pp.535-540.
https://search.emarefa.net/detail/BIM-347092
American Medical Association (AMA)
Abd al-Dayim, Ashraf A.& Azmi, Muhammad K.& Ahmad, Yusuf K.& Badr, Jamal A.& Husayn, Musa A.& al-Dahshan, Tariq. Role of statins in the treatment of chronic hepatitis C virus infection. Journal of the Egyptian Society of Parasitology. 2012. Vol. 42, no. 3, pp.535-540.
https://search.emarefa.net/detail/BIM-347092
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 539-540
Record ID
BIM-347092