Angiomyolipoma of the kidney : clinicopathological and immunohistochemical study
Joint Authors
Ushybh, Ghadah al-Sayyid
Ushybh, Nuha al-Sayyid
Source
Journal of the Egyptian National Cancer Institute
Issue
Vol. 25, Issue 3 (30 Sep. 2013), pp.125-134, 10 p.
Publisher
Cairo University National Cancer Institute
Publication Date
2013-09-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Topics
Abstract EN
Although angiomyolipoma (AML) is a relatively rare entity, it is the most common benign mesenchymal neoplasm of the kidney.
The aim of this study : to highlight the clinic pathological characteristics of AML and to assess the role of Human Melanoma Black-45 (HMB-45), Melan-A, smooth muscle actin (SMA), S-100 and cytokeratin in its diagnosis.
Materials and methods : the study included 15 cases of AML.
Clinical and radiological data were retrieved from the archival files and all cases were subjected to a histopathological evaluation as well as immunohistochemical staining for HMB-45, Melan-A, SMA, S-100, and cytokeratin.
Results : AML was more common in females (female : male = 4 : 1), the mean age was 6.45 ± 53.9 years.
60 % of patients were symptomatic while the remaining 40 % were asymptomatic.
A statistically significant relationship was found between size of the tumor and the presence of the symptoms (P = 0.02).
Patients with tumor size less than 4 cm were asymptomatic, while those with tumor size larger than 4 cm had different symptoms.
Thirteen cases were classic AML, while 2 cases were epithelioid AML.
Classic AML demonstrated admixture of fatty tissue, thick-walled blood vessels, and smooth muscle, while epithelioid AML was composed mainly of epithelioid cells and contained no fat.
HMB-45 was positive in all cases of AML (100 %), Melan-A was positive in 13/15 (87 %) while SMA was positive in 11/15 (73%) of AML with variable staining intensity.
All cases of AML were negative for S-100 and cytokeratin.
Conclusion : AMLs have characteristic clinicopathological and immunohistochemical features and their recognition is crucial for proper diagnosis and treatment.
American Psychological Association (APA)
Ushybh, Ghadah al-Sayyid& Ushybh, Nuha al-Sayyid. 2013. Angiomyolipoma of the kidney : clinicopathological and immunohistochemical study. Journal of the Egyptian National Cancer Institute،Vol. 25, no. 3, pp.125-134.
https://search.emarefa.net/detail/BIM-347212
Modern Language Association (MLA)
Ushybh, Ghadah al-Sayyid& Ushybh, Nuha al-Sayyid. Angiomyolipoma of the kidney : clinicopathological and immunohistochemical study. Journal of the Egyptian National Cancer Institute Vol. 25, no. 3 (Sep. 2013), pp.125-134.
https://search.emarefa.net/detail/BIM-347212
American Medical Association (AMA)
Ushybh, Ghadah al-Sayyid& Ushybh, Nuha al-Sayyid. Angiomyolipoma of the kidney : clinicopathological and immunohistochemical study. Journal of the Egyptian National Cancer Institute. 2013. Vol. 25, no. 3, pp.125-134.
https://search.emarefa.net/detail/BIM-347212
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 133-134
Record ID
BIM-347212