Histopathological changes in liver of mice after experimental envenomation with androctonus amoreuxi scorpion venom
Joint Authors
Muhallal, Mahmud E.
Sulayman, Bilal A.
Shukri, Nahlah M.
Khalid, Huwayda S.
Futayh, Hamdi A.
Source
Journal of the Egyptian Society of Parasitology
Issue
Vol. 43, Issue 2 (31 Aug. 2013), pp.447-456, 10 p.
Publisher
The Egyptian Society of Parasitology
Publication Date
2013-08-31
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Topics
Abstract EN
A total of 78 adult male Albino mice were divided into thirteen groups (6 mice in each).
One served as a control group and the other twelve groups were venom treated groups.
The mice of treated groups were injected with 0.1 ml saline solution in which a particular amount of scorpion venom.
The first 6 groups were subcutaneously injected with 1/2 LD50 (0.05 g/g body weight), while the other 6 groups were injected with 1/4 LD 50 (0.025 g/g body weight) by the same route.
The animals from each group were anesthetized with ethyl ether and sacrificed at different time intervals (3, 6, 9, 12 hrs, 4 & 7days post toxin administration).
The microscopic examination of liver tissue obtained from envenomed animals showed variable histopathological changes being severely increased with the time interval of envenoming.
The most obvious changes in the liver were acute cellular swelling, hydropic degeneration, congestion of central veins and portal blood vessels.
Besides, extramedullary hematopoiesis and invaginations in nuclei of hepatic cells, with formation of intranuclear cytoplasmic inclusions were observed.
American Psychological Association (APA)
Futayh, Hamdi A.& Shukri, Nahlah M.& Sulayman, Bilal A.& Muhallal, Mahmud E.& Khalid, Huwayda S.. 2013. Histopathological changes in liver of mice after experimental envenomation with androctonus amoreuxi scorpion venom. Journal of the Egyptian Society of Parasitology،Vol. 43, no. 2, pp.447-456.
https://search.emarefa.net/detail/BIM-347220
Modern Language Association (MLA)
Shukri, Nahlah M.…[et al.]. Histopathological changes in liver of mice after experimental envenomation with androctonus amoreuxi scorpion venom. Journal of the Egyptian Society of Parasitology Vol. 43, no. 2 (Aug. 2013), pp.447-456.
https://search.emarefa.net/detail/BIM-347220
American Medical Association (AMA)
Futayh, Hamdi A.& Shukri, Nahlah M.& Sulayman, Bilal A.& Muhallal, Mahmud E.& Khalid, Huwayda S.. Histopathological changes in liver of mice after experimental envenomation with androctonus amoreuxi scorpion venom. Journal of the Egyptian Society of Parasitology. 2013. Vol. 43, no. 2, pp.447-456.
https://search.emarefa.net/detail/BIM-347220
Data Type
Journal Articles
Language
English
Notes
Includes appendicx : p. 456
Record ID
BIM-347220