Evaluation of garlic plant and indinavir® drug efficacy in the treatment of cryptosporidiosis in experimentally immumosuppressed rats
Joint Authors
Tawlah, Fawziyah H.
al-Shafii, Amal A.
al-Rashidi, Hayah S.
Source
Journal of the Egyptian Society of Parasitology
Issue
Vol. 42, Issue 2 (31 Aug. 2012), pp.321-328, 8 p.
Publisher
The Egyptian Society of Parasitology
Publication Date
2012-08-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Topics
Abstract EN
The present study evaluated the efficacy of garlic plant and Indinavir® on cryptosporidiosis in experimentally immunosuppressed infected rats.
One hundred forty five Wister rats aging 3 weeks were divided into five groups : GI : normal control, GII : Indinavir treated control, GIII : immunosuppressed infected, GIV : immunosuppressed infected and treated with garlic and GV : immunosuppressed infected and treated with Indinavir.
All were subjected to clinical, parasitological and histopathological examination at different days post infection (P.I).
The results showed that in GIII, all rats had diarrhea, loss of appetite, weakness and limited movement, with 51.4 % death rate.
In both treated groups, some rats regained activities, with death rate of 33.3 % (GV) and non GIV.
There was significant decrease in the number of excreted oocysts at 5th and 10th day post treatment (P.T.) in treated groups.
One week P.T., in GIV, the number of excreted oocysts had continued in decreasing while in GV, it was insignificantly increased.
No cure rate was detected in both treated groups as oocysts still excreted till the end of experiment.
The histopathological changes improved in treated groups in spite of the presence of some parasites on the epithelial surfaces of ileum.
American Psychological Association (APA)
Tawlah, Fawziyah H.& al-Shafii, Amal A.& al-Rashidi, Hayah S.. 2012. Evaluation of garlic plant and indinavir® drug efficacy in the treatment of cryptosporidiosis in experimentally immumosuppressed rats. Journal of the Egyptian Society of Parasitology،Vol. 42, no. 2, pp.321-328.
https://search.emarefa.net/detail/BIM-347345
Modern Language Association (MLA)
Tawlah, Fawziyah H.…[et al.]. Evaluation of garlic plant and indinavir® drug efficacy in the treatment of cryptosporidiosis in experimentally immumosuppressed rats. Journal of the Egyptian Society of Parasitology Vol. 42, no. 2 (Aug. 2012), pp.321-328.
https://search.emarefa.net/detail/BIM-347345
American Medical Association (AMA)
Tawlah, Fawziyah H.& al-Shafii, Amal A.& al-Rashidi, Hayah S.. Evaluation of garlic plant and indinavir® drug efficacy in the treatment of cryptosporidiosis in experimentally immumosuppressed rats. Journal of the Egyptian Society of Parasitology. 2012. Vol. 42, no. 2, pp.321-328.
https://search.emarefa.net/detail/BIM-347345
Data Type
Journal Articles
Language
English
Notes
Includes appendices : p. 327-328
Record ID
BIM-347345