Serum SP-D levels AS A biomarker of lung injury in children suffering of bronchopneumonia

Abstract EN

The efficacy of SP-D concentration as a useful biomarker of the severity of lung injury in children with bronchopneumonia with or without chronic airway disease was studied.

A total of 48 patients (2 to 4 years old) diagnosed bronchopneumonia were admitted to Department of Pediatrics, Al-Dar hospital, Al-Madinah, Saudi Arabia over the year 2009.

They were divided into two groups : G1 included patients without any underlying disease and G2 included asthmatic patients.

They were assigned to one of three categories.

Stage A patients without oxygen dosage, Stage B patients required oxygen dosage, and Stage C patients required ICU admission.

We evaluated baseline characteristics, clinical features, and serum SP-D concentration in G1, G2, and G3a (healthy control cross-matched infants).

The mean serum SP-D concentrations in G1 and G2 were higher than those in G3 18.7 ±39.7, 46.2 ± 118.7) ng / ml, respectively), but also higher in G2 than in G1 36.7 ± 109.8, 52.8 ± 149.9) ng / ml, respectively).

The mean serum SP-D concentrations were higher in Stage C than in Stages A or B patients, and mean serum SP-D concentrations were higher in Stage B than in Stage A.