Role of prophylactic antibiotic in elective laparoscopic cholecystectomy

Abstract EN

This prospective study was conducted to investigate the efficacy of single-dose Ceftazidime as a prophylactic antibiotic to prevent surgical site infections in lowrisk patients undergoing LC.

Two hundred patients included in the study were randomly divided into two groups (100 each) : G1 : patients received intravenous Ceftazidime within 60 minutes prior to surgery and G2 : received intravenous placebo (10 ml isotonic sodium chloride 0.9 % solution).

All patients were invited for examination 10, 20 and 30 days post-operatively and any post-operative complications were recorded and managed.

Preoperatively ; there was no significant differences existed between the 2 groups regarding sex, age ; body mass index and ASA score.

Also, the duration of LC surgery, incidence of intra-operative gallbladder perforations and spill of bile or stones, incidents of intra-operative bleeding from either cystic artery or gall bladder liver bed and mean postoperative hospital stay were found not significantly different between the 2 groups.

Post operatively there was no statistical difference regarding the surgical site infection between the two groups.