Systemic therapy for hepatocellular carcinoma (HCC) : from bench to bedside
Author
Source
Journal of the Egyptian National Cancer Institute
Issue
Vol. 25, Issue 4 (31 Dec. 2013), pp.165-171, 7 p.
Publisher
Cairo University National Cancer Institute
Publication Date
2013-12-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Topics
Abstract EN
Primary liver cancer is the fifth most common cancer worldwide and the third most common cause of cancer mortality.
For patients with early resectable disease, surgical resection or transplantation is considered a potentially curative modality for hepatocellular carcinoma (HCC); on the other hand, for patients with unresectable or metastatic disease, treatment is essentially palliative and prior to the approval of sorafenib, there was no globally approved systemic treatment for patients presenting with unresectable or metastatic HCC.
Sorafenib is the only systemic treatment to demonstrate a statistically significant but modest overall survival benefit in a large phase III trial.
Thus, novel systemic approaches represent a high unmet medical need in advanced HCC.
In this review article, we will try to take a journey through the history of systemic therapeutic options for HCC passing through the current standard options and exploring the potential new systemic options for this disease.
American Psychological Association (APA)
Abd al-Rahman, Umar. 2013. Systemic therapy for hepatocellular carcinoma (HCC) : from bench to bedside. Journal of the Egyptian National Cancer Institute،Vol. 25, no. 4, pp.165-171.
https://search.emarefa.net/detail/BIM-347847
Modern Language Association (MLA)
Abd al-Rahman, Umar. Systemic therapy for hepatocellular carcinoma (HCC) : from bench to bedside. Journal of the Egyptian National Cancer Institute Vol. 25, no. 4 (Dec. 2013), pp.165-171.
https://search.emarefa.net/detail/BIM-347847
American Medical Association (AMA)
Abd al-Rahman, Umar. Systemic therapy for hepatocellular carcinoma (HCC) : from bench to bedside. Journal of the Egyptian National Cancer Institute. 2013. Vol. 25, no. 4, pp.165-171.
https://search.emarefa.net/detail/BIM-347847
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 169-171
Record ID
BIM-347847