Effect of immunosuppression on the course of cryptosporidiosis experimentally
Joint Authors
Toulah, Fawziyah H.
al-Shafii, Amal A.
al-Rashidi, Hayah S.
Source
Journal of the Egyptian Society of Parasitology
Issue
Vol. 42, Issue 3 (31 Dec. 2012), pp.649-659, 11 p.
Publisher
The Egyptian Society of Parasitology
Publication Date
2012-12-31
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Topics
Abstract EN
This study evaluated the effect of immunosuppression on experimental cryptosporidiosis, by parasitological and histopathological studies at different days post infection (p.i).
A total of one hundred five clean laboratory bred male Wister rats were divided into four groups : normal control group (GI), infected group (GII), immunosuppressed control group (GIII) and immunosuppressed infected group (GIV).
The infection was done by inoculation orally with 105 Cryptosporidium oocysts in 0.1ml PBS.
The immunosuppression was done by administration of cytotoxic drug (Endoxan) intraperitoneal in a dose of 5mg / kg / d for 4 weeks.
The results showed that in GII, most of animals attained its activities without apparent clinical symptoms except some of them had diarrhea while in GIV, all had diarrhea, loss of appetite, weakness, lethargy and hair loss.
The death rate was 10 % in GII while in GIV was 51.4 %.
The infection rate among GII was 95 % and GIV was 100 %.
The infection intensity was higher in GIV than in GIII and the greatest number of excreted oocysts was observed on day 15th post-infection (PI) in GIV and on day 11th PI in GII.
The histopathological changes in the ileum were more advanced in GIV.
American Psychological Association (APA)
Toulah, Fawziyah H.& al-Shafii, Amal A.& al-Rashidi, Hayah S.. 2012. Effect of immunosuppression on the course of cryptosporidiosis experimentally. Journal of the Egyptian Society of Parasitology،Vol. 42, no. 3, pp.649-659.
https://search.emarefa.net/detail/BIM-347944
Modern Language Association (MLA)
Toulah, Fawziyah H.…[et al.]. Effect of immunosuppression on the course of cryptosporidiosis experimentally. Journal of the Egyptian Society of Parasitology Vol. 42, no. 3 (Dec. 2012), pp.649-659.
https://search.emarefa.net/detail/BIM-347944
American Medical Association (AMA)
Toulah, Fawziyah H.& al-Shafii, Amal A.& al-Rashidi, Hayah S.. Effect of immunosuppression on the course of cryptosporidiosis experimentally. Journal of the Egyptian Society of Parasitology. 2012. Vol. 42, no. 3, pp.649-659.
https://search.emarefa.net/detail/BIM-347944
Data Type
Journal Articles
Language
English
Notes
Includes appendices : p. 657-659
Record ID
BIM-347944