Spasmolytic activity of Ammi visnaga seeds on isolated rabbit jejunum

Abstract EN

Ammi visnaga seeds were investigated for their effect on contractibility of small intestine of rabbit by using kymograph.

Pharmacological study of the plant compare between intestinal contraction after the addition of an agonist drug alone and intestinal contraction after the addition of both relaxation plant as antagonist followed by the addition of an agonist drug.

Ammi visnaga showed a statistically significant relaxation effect in a dose dependent manner.It is concluded that A.

visnaga cause reduction of intestinal contraction.

Neostigmine and pilocarpine effect was inhibited by the administration of Ammi visnaga, neostigmine only cause a parallel shift to the right of the dose response curve, this effect of neostigmine is more potent than pilocarpine probably due to tissue selectively of neostigmine on the muscarnic receptors of the small intestine.