Effect of the aqueous extract of celery (Apium graveolens)‎ seeds, apple vinegar and their combination on animal models of pain

Abstract EN

This study was conducted to characterize the analgesic effect of the aqueous extract of celery (Apium graveolens) seeds using three animal models of induced pain in mice: hot plate, tail flick and formalin tests.

The analgesic effect of apple vinegar was also tested alone and in combination with the aqueous extract of celery.

The results showed that the oral administration of aqueous extract of celery caused (80.5%) increase in hot plate time, (102.9 %) increase in tail flick time and (40.1 %) decrease in number of lickings and bitings with respect to preadministration number.

Also the mice that given apple vinegar only caused (78.9 %) increase in hot plate time, (82.2 %) increase in tail flick time and (46.6 %) decrease in number of lickings and bitings with respect to pre-administration levels.

When celery extract was mixed with vinegar, it showed only (84.6 %) increase in hot plate test, (76.9 %) increase in tail flick test and (62.3 %) in formalin test.

It can be concluded that both the aqueous extract of celery and apple vinegar have analgesic effect in all the three pain models.

Their combination did not enhance the effect of each other one hour after administration except a mild increase in formalin test.