Study the effects of drenching of ethanolic extract of Taraxacum Officinale leaves and atrovastatin on serum enzymatic activity; cholesterol level; reproductive efficiency and on the structural characteristics of pituitary-thyroid-ovarian-uterine axis of local adult cholecystoctomised female rabbits

Abstract EN

This study had been done on twenty four healthy adult local female rabbits of _ mean body weight of 2 kgm and mean age of 5 months were randomly allocated into four groups of six ainmals eash; all groups were fed during the period of experiment on a diet contained 0.5 % cholesterol and 14% coconut oil.

The first group was regarded as control and received 3ml of physiological saline orally‘ for a month.

The second group was drenched ethanolic extract of Taraxacum ojficirzale (500 mg/kg/day) for one month; the third group first subjected to cholecystoctomy (removal of gall bladder) then drenched 500 mg/kg/day ethanolic extract of T.

oflicinale for month also.

The fourth group was treated with atrovastatin (0.4 mg/kg/day) for one month also.

Those females were joined with males after treatment for a week to study the effect on fertility and reproductive capacity and on fetal growth.

Blood samples were taken from all groups at the end of the treatment to know the effect on serum cholesterol and on enzymatic activity then after killing the animals the following organs were taken for histological study.

They are pituitary and thyroid glands; ovaries and uterin from each animal of each .

group.

The following results were obtained:- 1.

The ethanolic extract of Taraxacum ofiicinale caused highly significant increase (p<0.01) in SGOT.

2.

Atrovastatin caused significant increase i(p<0.05) in SGOT.

3.

Drenching Tofiicinale extract didnot cause any significant change in SGOT of cholecystoctomised female rabbits.

’ 4.

The ethanolic extract of Tofficinale and atorvastatin had caused significant decrease (p<0.05) of SGPT in intact female rabbits but caused highly significant decrease