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Estimation the important relationship between the biological activity and the stereochemicalstructure of the preparing compounds
Other Title(s)
استنباط العلاقة المهمة بين الفعالية الحياتية و الشكل الفراغي لبعض المركبات المحضرة
Joint Authors
al-Darraji, Ala Husayn K.
al-Saidi, Walid Muhsin
Source
Basrah Journal of Veterinary Research
Issue
Vol. 5, Issue 2 (31 Dec. 2006), pp.153-159, 7 p.
Publisher
University of Basrah College of Veterinary Medicine
Publication Date
2006-12-31
Country of Publication
Iraq
No. of Pages
7
Main Subjects
Topics
Abstract AR
بالإمكان تحضير العديد من الأدوية الجديدة بالاعتماد على العلاقة المهمة التي تربط الفعالية الحياتية (الفعالية ضد الجراثيم) و الشكل الفراغي للمركبات الكيميائية. لتوضيح هذه العلاقة تم تحضير مركبين و اختبرت فعاليتهما الحياتية على مجاميع من البكتريا السالبة و الموجبة بالإضافة إلى الفطر Candida albicans إذ أظهر أحد المركبين (رقم 1) فعالية أكبر من المركب الآخر (رقم 2). دراسة أشكال المركبين الفراغية أدت إلى استنباط العلاقة المهمة التي اعتمدت على خمسة عوامل أو صفات يجب توفرها في المركب ليكون أكثر فعالية. لغرض تأكيد العلاقة بين الفعالية و الشكل الفراغي، أظهر المركب رقم (3) فعالية أعلى من المركبين السابقين، علما أن المركبات تم تمييزها بواسطة درجة الانصهار، اختبارات الإذابة، جهاز تحليل العناصر، طيف الأشعة تحت الحمراء و طيف الأشعة فوق البنفسجية المرئية.
Abstract EN
It can be prepared a good drug or antibiotic depending on this research .its same as build a beautiful house depending on a good building factors, this research is about the important relation between the biological activity (the activity against the microbes) and stereochemical structure of the preparing compounds .To obtain this relation two ‘compounds has been prepared and tested on different species - r j (§_t.aureus, _F:._c_ofi, candida albicans), one of these two compounds has show more activity than the other even the difference between them is simple, this question was push us to study the more active compound (compound (l)), why it more active against the microbes, _ also this question led us to estimate the important relation five factors effecting the relation, th1s relation was obtained not from the two compounds only, but depending on more than these compounds the relation was obtained, also preparing compounds in this research are enough to illustrate the five factors leading to the important relation.
_ ‘To understanding the research idea or the important relation, compound (3) was _ prepared which its more active than the two compounds.
, ' All the three compounds have identify by melting point, solubility test, CHNSO analyzer, l.R., and uv-visible spectra
American Psychological Association (APA)
al-Darraji, Ala Husayn K.& al-Saidi, Walid Muhsin. 2006. Estimation the important relationship between the biological activity and the stereochemicalstructure of the preparing compounds. Basrah Journal of Veterinary Research،Vol. 5, no. 2, pp.153-159.
https://search.emarefa.net/detail/BIM-348611
Modern Language Association (MLA)
al-Darraji, Ala Husayn K.& al-Saidi, Walid Muhsin. Estimation the important relationship between the biological activity and the stereochemicalstructure of the preparing compounds. Basrah Journal of Veterinary Research Vol. 5, no. 2 (2006), pp.153-159.
https://search.emarefa.net/detail/BIM-348611
American Medical Association (AMA)
al-Darraji, Ala Husayn K.& al-Saidi, Walid Muhsin. Estimation the important relationship between the biological activity and the stereochemicalstructure of the preparing compounds. Basrah Journal of Veterinary Research. 2006. Vol. 5, no. 2, pp.153-159.
https://search.emarefa.net/detail/BIM-348611
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 158-159
Record ID
BIM-348611