Topical activity of Aloe vera (A. vera )‎ extract on excision wound-healing of skin in rabbits : clinical and histological study

Abstract EN

plant /I/ac van: is a green succulent .cactus-like plant belonging to the lily family ,The.plant has a history of use in folk medicine for skin and otherdisorders.

The objective of the study presented in this report was to screen the extracts of this plant for its wound- - healing properties based on its traditional use for wound healing.

ethanolic extracts was prepared for topical applications.

The dose used was 150 mg/kg daily for 10 days, using the excision wound model in rabbits.

Carboxymethyl cellulose (1%) was used as control in .

‘ topical studies.

Animals were randomized divided to treatment or control groups, .

Wound areas were measured.

At the day Il',skin .tissue was excised for histological studies" .

Wound areas reduced significantly in all treatment groups compared to respective controls (P < .001).

Histology outcomes were consistent with changes in the treatment groups.

No differences were detected within the treatment groups.

The study permits the conclusion that Aloe Vera has wound—hea‘ling potential