Synthesis and characterization of some new 1, 3, 4-thiadiazol derivatives

Abstract EN

Fifteen compounds of 2-amino-5-mercapto-1,3,4-thiadiazole derivatives were synthesized and classified into three groups A, B and C.

Group A compounds were prepared by condensation reaction of 2-amino-5-mercapto-1,3,4-thiadiazole with some para substituted benzaldehyde and then reacted with ethyl iodide to give the same group C compounds.

Group B compounds were synthesized by the reaction of 2-amino-5-methylthio-1,3,4- thiadiazole with the same aldehyde.

While, group C compounds were prepared in reverse method to group A compounds by condensation reaction of 2-amino-5ethylthio-1,3,4- thiadiazole with the same para substituted benzaldehyde.

All compounds were characterized by elemental analysis, IR and 1HNMR spectral data.

These data were confirmed the structural formula of all synthesized compounds.