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Conductometric determination of the stability constants of the quinolone antibacterial agents levofloxacin and sparfloxacin with divalent metal ions
Joint Authors
al-Mustafa, Jamil
Shannar, Abir
Source
Issue
Vol. 8, Issue 4 (31 Dec. 2013), pp.237-246, 10 p.
Publisher
Yarmouk University Deanship of Research and Graduate Studies
Publication Date
2013-12-31
Country of Publication
Jordan
No. of Pages
10
Main Subjects
Topics
Abstract EN
The stability of the metal ion complexes of the fluoroquinolone antibiotics sparfloxacin and levofloxacin with the divalent magnesium, calcium, barium and nickel perchlorates has been investigated by electrical conductivity in methanol at 25oC.
Under the experimental conditions used, it was found that the metal ions interact with ligands in the zwitterionic state leading to the formation of positively charged complexes.
The complexes of levofloxacin with the four metal ions are slightly more stable than those of sparfloxacin due to the differences in the substitution pattern between the two ligands.
The stability of the complexes formed decreases in the order Mg2+ > Ca2+ > Ni2+ > Ba2+.
The observed order of decrease of the complex stability is attributed to the variation in ionic radii between metal ions and to the nature of the interaction between the ligands and the metal ions.
American Psychological Association (APA)
al-Mustafa, Jamil& Shannar, Abir. 2013. Conductometric determination of the stability constants of the quinolone antibacterial agents levofloxacin and sparfloxacin with divalent metal ions. Jordan Journal of Chemistry،Vol. 8, no. 4, pp.237-246.
https://search.emarefa.net/detail/BIM-349686
Modern Language Association (MLA)
al-Mustafa, Jamil& Shannar, Abir. Conductometric determination of the stability constants of the quinolone antibacterial agents levofloxacin and sparfloxacin with divalent metal ions. Jordan Journal of Chemistry Vol. 8, no. 4 (Dec. 2013), pp.237-246.
https://search.emarefa.net/detail/BIM-349686
American Medical Association (AMA)
al-Mustafa, Jamil& Shannar, Abir. Conductometric determination of the stability constants of the quinolone antibacterial agents levofloxacin and sparfloxacin with divalent metal ions. Jordan Journal of Chemistry. 2013. Vol. 8, no. 4, pp.237-246.
https://search.emarefa.net/detail/BIM-349686
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 245-246
Record ID
BIM-349686