Ciprofloxacin but not amoxicillin significantly elevated serum peroxynitrite level in patients with enteric (typhoid fever) : in vitro study
Joint Authors
al-Nimr, Marwan S. M.
al-Jarrah, Nada Abd al-Husayn
Source
Journal of the Faculty of Medicine Baghdad
Issue
Vol. 48, Issue 3 (30 Sep. 2006), pp.305-308, 4 p.
Publisher
University of Baghdad Faculty of Medicine
Publication Date
2006-09-30
Country of Publication
Iraq
No. of Pages
4
Main Subjects
Topics
Abstract EN
Peroxynitrite is one intermediate of reactive nitrogen species with bactericidal and cylotoxic effects.
Fluoroquinolones.
drugs used for salmonella infections, are interacted v\ith nitrogen species and their baeterieida effect is influenced by these species.
This study aims to assess serum peroxynitrite level in patients with enteric (typhoid) fever and.
to investigate the effect of ciprofloxacin or amoxicillin on serum peroxynitrite level as well as in aqueous buffer solution in vitro.
Thirty patients with enteric fever diagnosed clinically and serologically and twenty healthy individuals served as controls were admitted in this study.
None of our sample was received anli-salmonellosis agents.
Our results show that serum peroxynitrite level tended to be significantly less in patients with typhoid fever in comparison with controls.
In in vitro experimental model, ciprofloxacin but not amoxicillin at 6.
25 ug elevate significantly serum peroxynitrite level.
In aqueous solution, the ability of ciprofloxacin to produce peroxynitrite is higher than that of amoxicillin.
We conclude that Ciprofloxacin.
as bactericidal agent against salmonellosis, may act via producing or elevating peroxynitrite level.
American Psychological Association (APA)
al-Nimr, Marwan S. M.& al-Jarrah, Nada Abd al-Husayn. 2006. Ciprofloxacin but not amoxicillin significantly elevated serum peroxynitrite level in patients with enteric (typhoid fever) : in vitro study. Journal of the Faculty of Medicine Baghdad،Vol. 48, no. 3, pp.305-308.
https://search.emarefa.net/detail/BIM-349800
Modern Language Association (MLA)
al-Nimr, Marwan S. M.& al-Jarrah, Nada Abd al-Husayn. Ciprofloxacin but not amoxicillin significantly elevated serum peroxynitrite level in patients with enteric (typhoid fever) : in vitro study. Journal of the Faculty of Medicine Baghdad Vol. 48, no. 3 (2006), pp.305-308.
https://search.emarefa.net/detail/BIM-349800
American Medical Association (AMA)
al-Nimr, Marwan S. M.& al-Jarrah, Nada Abd al-Husayn. Ciprofloxacin but not amoxicillin significantly elevated serum peroxynitrite level in patients with enteric (typhoid fever) : in vitro study. Journal of the Faculty of Medicine Baghdad. 2006. Vol. 48, no. 3, pp.305-308.
https://search.emarefa.net/detail/BIM-349800
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 308
Record ID
BIM-349800