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Spontaneous abortion and failure of human cytotrophoblasts to adopt a vascular adhesion phenotype
Joint Authors
al-Ubaydi, Asma Baqir
Husayn, Ala Gani
Shamran, Haydar Ahmad
Source
Journal of the Faculty of Medicine Baghdad
Issue
Vol. 48, Issue 4 (31 Dec. 2006), pp.402-406, 5 p.
Publisher
University of Baghdad Faculty of Medicine
Publication Date
2006-12-31
Country of Publication
Iraq
No. of Pages
5
Main Subjects
Topics
Abstract EN
Background : Differentiating cytotrophoblasts transform their adhesion receptor phonotype so as to resemble the endothelial cells they replace a process that is required for normal placentation, and any defect in this adhesion phenotype switch might lead to pregnancy failure.
Patients and Methods : Curate samples of the materno-fetal interface were taken from 20 women with spontaneous first trimester abortion and 6 control women undergone elective termination of pregnancy in the first trimester.
Immunohistochemistry analysis of paraffin embedded sections of these curate samples was performed using monoclonal antibodies for cytokeratin, PECAM-1 and VCAM-1.
Results: Cytokeratin showed positive immunostaing of the cytotrophoblasts lining the blood vessels, and PECAM-1 was positive in the cytotrophoblasts in only two cases who had elective termination of their pregnancy, while VCAM-1 immunostaining of the cytotrophoblasts was positive in three cases that had elective termination of pregnancy and only two cases that had spontaneous abortion.
Conclusion : Defective expression of endothelial cell adhesion molecules in human cytotrophoblasts might predispose to abnormal placentation, pregnancy failure and subsequent abortion.
American Psychological Association (APA)
al-Ubaydi, Asma Baqir& Husayn, Ala Gani& Shamran, Haydar Ahmad. 2006. Spontaneous abortion and failure of human cytotrophoblasts to adopt a vascular adhesion phenotype. Journal of the Faculty of Medicine Baghdad،Vol. 48, no. 4, pp.402-406.
https://search.emarefa.net/detail/BIM-349937
Modern Language Association (MLA)
al-Ubaydi, Asma Baqir…[et al.]. Spontaneous abortion and failure of human cytotrophoblasts to adopt a vascular adhesion phenotype. Journal of the Faculty of Medicine Baghdad Vol. 48, no. 4 (2006), pp.402-406.
https://search.emarefa.net/detail/BIM-349937
American Medical Association (AMA)
al-Ubaydi, Asma Baqir& Husayn, Ala Gani& Shamran, Haydar Ahmad. Spontaneous abortion and failure of human cytotrophoblasts to adopt a vascular adhesion phenotype. Journal of the Faculty of Medicine Baghdad. 2006. Vol. 48, no. 4, pp.402-406.
https://search.emarefa.net/detail/BIM-349937
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 405-406
Record ID
BIM-349937