![](/images/graphics-bg.png)
Effect of early treatment with tirofiban on initial TIMI grade 3 flow of patients with ST elevation myocardial infarction
Joint Authors
Salarifar, Mojtaba
Musawi, Mahdi
Yousefpour, Narjis
Nematipour, Ibrahim
Kassaian, Sayyid Ibrahim
Poorhosseini, Hamid Rida
Ali, Ali Muhammad Hajizein
Doosti, Muhammad Ali
Aghajani, Hasan
Nozari, Yunus
Amirzadegan, Ali Rida
Bozorgi, Ali
Jinab, Yasir
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 16, Issue 1 (31 Jan. 2014), pp.1-9, 9 p.
Publisher
Publication Date
2014-01-31
Country of Publication
United Arab Emirates
No. of Pages
9
Main Subjects
Abstract EN
Background : before primary percutaneous coronary intervention (PCI) in patients with ST elevation myocardial infarction (STEMI), it is not clear whether a routine early administration of glycoprotein IIb / IIIa inhibitors in the emergency ward is beneficial or their administration in selected cases in the catheterization laboratory.
Objectives : the present randomized clinical trial sought to investigate whether an earlier administration of Tirofiban could exert any impact on TIMI grade 3 flows and ST resolution in the electrocardiography of patients with STEMI before primary PCI.
Materials and Methods : patients with STEMI within twelve hours of symptom commencement were included if primary PCI was planned to be performed within ninety minutes of admission and excluded if they had contraindications for Tirofiban.
Seventy patients were randomized to receive 25 μg / kg of bolus Tirofiban early in the emergency ward (the early Tirofiban group) in three minutes and 70 did not receive Tirofiban (the control group).
The primary endpoint of the study was a Thrombolysis in Myocardial Infarction (TIMI) grade 3 flows on the initial angiogram.
The study is registered as IRCT201105126463N1 in: www.irct.ir.
Results : the study population had a mean age of 57.17 ± 10.09 years and included 79.3 % males.
TIMI grade 3 flow was seen in 15 (21.4 %) patients of the Tirofiban group and 7 (10 %) of the control group (P = 0.06, odds ratio = 0.407, and 95 % confidence interval = 0.155-1.072).
Complete ST resolution was seen in 30 (42.9 %) patients of the Tirofiban group and 34 (48.6 %) of the control group (P = 0.5).
Conclusion : although TIMI grade 3 flows trended to be higher in the patients who received early Tirofiban in the emergency ward, the difference did not constitute statistical significance and possible benefits, therefore, require further clarification.
American Psychological Association (APA)
Salarifar, Mojtaba& Musawi, Mahdi& Yousefpour, Narjis& Nematipour, Ibrahim& Kassaian, Sayyid Ibrahim& Poorhosseini, Hamid Rida…[et al.]. 2014. Effect of early treatment with tirofiban on initial TIMI grade 3 flow of patients with ST elevation myocardial infarction. Iranian Red Crescent Medical Journal،Vol. 16, no. 1, pp.1-9.
https://search.emarefa.net/detail/BIM-350545
Modern Language Association (MLA)
Salarifar, Mojtaba…[et al.]. Effect of early treatment with tirofiban on initial TIMI grade 3 flow of patients with ST elevation myocardial infarction. Iranian Red Crescent Medical Journal Vol. 16, no. 1 (Jan. 2014), pp.1-9.
https://search.emarefa.net/detail/BIM-350545
American Medical Association (AMA)
Salarifar, Mojtaba& Musawi, Mahdi& Yousefpour, Narjis& Nematipour, Ibrahim& Kassaian, Sayyid Ibrahim& Poorhosseini, Hamid Rida…[et al.]. Effect of early treatment with tirofiban on initial TIMI grade 3 flow of patients with ST elevation myocardial infarction. Iranian Red Crescent Medical Journal. 2014. Vol. 16, no. 1, pp.1-9.
https://search.emarefa.net/detail/BIM-350545
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 7-9
Record ID
BIM-350545