The effect of aging on cryglobulin responses in pulmonary tuberculosis patients

Abstract EN

In the present work attempts were, made to verify the hypothesis that aging may suppress cry globulin responses among pulmonary tuberculus patient.

Two main groups of test pulmonary tuberculus patients one with age group of ≥ 60 years (aged) and the other with age group of ≤ 55 years (non aged) patients.

These two groups were equaly subdivided into males and females subgroups.

Apparently healthy normal subjects were elected as control with same age groups as test patients.

The test and control groups were subjected to study of Cryoglobulinemia responses in accordance with Irish guide line for study of Cryoglobulinemia.

The aged patients of ≥ 60 years old showed low Cryocrit percent, low CRP levels and high RF level, C3, C4 and IgA in comparison to non aged ≤ 55 years old patients which showed high Cryocrit percent, high CRP levels and low RF level and IgA levels.

This Cryoglobulinemia associated is secondary to Pulmonary Tuberculosis and of mixed IgG-IgAIgM types.

Cryocrit percent, RF, C3, C4 and Igs class determination proved to be valid battery of tests for immunodiagnosis of Cryoglobulinemia and for testing the effect of aging.