Studying the therapeutic effect of watery &alcoholic extracts extract of apium graveolens leaves on urinary tract infections caused by staphylococcus aureus in rabbits

Abstract EN

This study was designed to evaluate the effects of the watery and alcoholic extracts from leaves of Apium graveolens in vitro on pathogenic Staphylococcus aureus bacteria and studying the effect of watery extract on Staphylococcus aureus in urinary system in vivo.

The results showed the watery and alcoholic extracts from Apium graveolens leaves have antibacterial activity against Staphylococcus aureus.

It was more sensitive toward watery extract of celery concentration (100 %).

In addition to inhibit the virulence factors for these bacteria which include production of coagulase, protease and hemolysin.

According to the results, bacteria was injected intraperitonialy as experimental infection in rabbits (vivo) which cause morphological and histopathological degenerative lesion of kidney cortex and medulla tissue in addition to change of renal profile test that include blood urea nitrogen, creatinine, creatinine kinase, uric acid and calcium.

However, after injection of watery extract of Apium graveolens intraperitonialy in rabbits, significant improvement (p ≤ 0.01) had been occurred in the value of blood urea nitrogen, creatinine and creatinine kinase.

Calcium and uric acid had a less improvement but don't reach significant degree (p ≥ 0.01).

Histopathological studies confirm these results which include regeneration of degenerative lesion for medulla and kidney cortex with convoluted tubules tissue.

As general urinary system staphylococcal infection can be diminished by treatment with watery extraction of Apium graveolens leave.