Effect of melittin on mice stomach
Joint Authors
Abu Zinadah, Usamah
Rahmi, Tariq Rashid
al-Ahmari, Abir S.
Abduh, Fayizah
Source
Saudi Journal of Biological Sciences
Issue
Vol. 21, Issue 1 (31 Jan. 2014), pp.99-108, 10 p.
Publisher
Publication Date
2014-01-31
Country of Publication
Saudi Arabia
No. of Pages
10
Main Subjects
Topics
Abstract EN
Melittin, the main bee venom component, has many positive biological effects and a relatively low toxicity in various cell types.
However, there is no evidence of the effect of melittin on gastrointestinal cells.
In the present study, we investigated the histological and immuonohistochemical effects of melittin on mice stomach.
Adult male mice (Albino Swiss) were randomly divided into two groups (7 mice for each group) : control group and melittin only treated group (10 and 40 lg / kg).
These mice were sacrificed, then samples from the stomach were collected and prepared for histopathological studies by using alcian blue stain and immuonohistochemical studies by using smooth muscle actin (SMA) antibody.
Treatment with melittin alone do not cause any harmful effect on the stomach tissue where the microscopic examination of Alcian blue stained section showed the normal distribution of the mucous secreting cells of the stomach tissues.
On other hand, no changes were observed on smooth muscle cells.
This study demonstrated the safety of using melittin on gastrointestinal tissues if used in definite dose and for suitable duration, which offers an opportunity for its use as a treatment for many diseases of the gastrointestinal tract.
American Psychological Association (APA)
Abu Zinadah, Usamah& Rahmi, Tariq Rashid& al-Ahmari, Abir S.& Abduh, Fayizah. 2014. Effect of melittin on mice stomach. Saudi Journal of Biological Sciences،Vol. 21, no. 1, pp.99-108.
https://search.emarefa.net/detail/BIM-351179
Modern Language Association (MLA)
Abu Zinadah, Usamah…[et al.]. Effect of melittin on mice stomach. Saudi Journal of Biological Sciences Vol. 21, no. 1 (Jan. 2014), pp.99-108.
https://search.emarefa.net/detail/BIM-351179
American Medical Association (AMA)
Abu Zinadah, Usamah& Rahmi, Tariq Rashid& al-Ahmari, Abir S.& Abduh, Fayizah. Effect of melittin on mice stomach. Saudi Journal of Biological Sciences. 2014. Vol. 21, no. 1, pp.99-108.
https://search.emarefa.net/detail/BIM-351179
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 107-108
Record ID
BIM-351179