Toxic-pathological study for long-term administration of aspirin in white rats

Abstract EN

The study showed that the starting dose 200 mg / kg for two months then increasing the dose to 400 mg / kg for another two months and finally the last two months the dose was 600 mg / kg.

during the study no clinical sings were seen and none of the treated animals died during the experiment.

This indicate tolerance of the rat to toxicity of the aspirin.

Only histopathological changes were seen after termination and those were in the liver, kidney, heart, pancreas and stomach.

These were as follows, vaculation and degeneration of liver cells, dilated cortical tubules in kidney, degeneration and vaculation of islet of pancreas, vaculation of myocardial muscle cells in the heart and erosion and ulceration of the glandular stomach.