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Teratogenic effects of the organophosphate insecticide, malathion, on the skeleton of developing chick embryo : gross morphological study
Other Title(s)
التأثير التشوهي للملاثيون-مبيد حشري فوسفات عضوي-على الهيكل العظمي لجنين الكتكوت النامي : دراسة ظاهرية شكلية
Joint Authors
Abd al-Aziz, Huda Ahmad Muhammad
Salih, Muhammad Nabil Mahmud
Muhammad, Rifat Shihatah
Rifat, Haydi
Source
Issue
Vol. 30, Issue 3 (30 Sep. 2006), pp.9-40, 32 p.
Publisher
Assiut University Faculty of Medicine
Publication Date
2006-09-30
Country of Publication
Egypt
No. of Pages
32
Main Subjects
Topics
Abstract EN
The objective of this study was to document teratogenicity observed in chick embryos following administration of insecticide malathion in a dose of 2mg in 0.1 ml corn oil, and to suggest reasonable explanations for these anomalies.
A total number of 300 eggs of Gallus domesticus species were used.
After 48 hours of incubation eggs were divided into 5 groups, of 60 eggs each.
The individual groups were subdivided into control (20), and treated (40) eggs.
The control eggs were injected with 0.1 ml of corn oil, while the treated eggs were injected with 0.1 ml of corn oil in which 2 mg of malathion were dissolved.
Eggs of both control and treated groups were examined at the 5lh, 7lh, 10th, 14'h and 18lh days of incubation, for weight, mortality and morbidity, external malformations and body measurements.
Embryos were prepared for skeletal examination with A lizarin red stain and Victoria blue stain.
It is observed from the present study that lethality; external malformations and growth retardation, are characteristic features for malathion toxicity in chick embryo.
It is observed that, malathion mortality is more frequent in higher age groups (I4'h and 18'h days of incubation) while teratogenicity is more frequent in younger age groups (5,h and 7lh day of incubation).
Significant loss of weight in the treated groups is also observed.
The characteristic external malformations were in the form of short lower peak, parrot beak, short neck, wry neck, micromelia of both fore limbs and hind limbs.
In addition, tibiotarsal angulations and claw toes were also observed Abnormal feather distribution, persistence of mesencephalic bulge, eye anomalies and visceral herniation could also be detected.
It is concluded from this study that malathion injection is teratogenic in ckick embryo when given in the 2"d day of incubation.
The lethality detected in older age groups coidd be explained to be secondary to marked teratogenicity in vital organs such as heart (congestive heart failure) or neural tube defects.
The toxicity of malathion on developing chick embryo could be explained by its anticholinesterase action or its suppressive effect on nicotinamid dinucleotid (NAD) levels.
Also, its genotoxicity or mutagenicity could not be excluded.
American Psychological Association (APA)
Salih, Muhammad Nabil Mahmud& Muhammad, Rifat Shihatah& Abd al-Aziz, Huda Ahmad Muhammad& Rifat, Haydi. 2006. Teratogenic effects of the organophosphate insecticide, malathion, on the skeleton of developing chick embryo : gross morphological study. Assiut Medical Journal،Vol. 30, no. 3, pp.9-40.
https://search.emarefa.net/detail/BIM-35141
Modern Language Association (MLA)
Salih, Muhammad Nabil Mahmud…[et al.]. Teratogenic effects of the organophosphate insecticide, malathion, on the skeleton of developing chick embryo : gross morphological study. Assiut Medical Journal Vol. 30, no. 3 (Sep. 2006), pp.9-40.
https://search.emarefa.net/detail/BIM-35141
American Medical Association (AMA)
Salih, Muhammad Nabil Mahmud& Muhammad, Rifat Shihatah& Abd al-Aziz, Huda Ahmad Muhammad& Rifat, Haydi. Teratogenic effects of the organophosphate insecticide, malathion, on the skeleton of developing chick embryo : gross morphological study. Assiut Medical Journal. 2006. Vol. 30, no. 3, pp.9-40.
https://search.emarefa.net/detail/BIM-35141
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 37-40
Record ID
BIM-35141