Effect of reactive and non-reactive counterion micelles upon the alkaline degradation of indomethacin
Joint Authors
al-Luhidan, Hamad A.
al-Ayid, Abd Allah S.
Ali, Muhammad Sajid
al-Sulayman, Adil M.
Isa, Zuhayr A.
Source
Journal of Saudi Chemical Society
Issue
Vol. 18, Issue 1 (31 Jan. 2014), pp.77-83, 7 p.
Publisher
Publication Date
2014-01-31
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Topics
Abstract EN
In the present paper, kinetics of alkaline degradation of well-known drug, indomethacin (-2, 1- (-4 chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid), was studied in presence of excess [NaOH].
The rate of hydrolysis of substrate was independent of the [indomethacin] though it increased linearly with increasing the hydroxide ion concentration with a positive slope, suggesting the following rate law: kobs= k1 OHCationic surfactants having non-reactive ions (cetyltrimethylammonium bromide, CTAB and cetyltrimethylammonium sulfate (CTA) 2SO4) first increased the rate constants at lower concentrations and then decreased it at higher concentrations while in case of the surfactant with reactive counterions (cetyltrimethylammonium hydroxide, CTAOH) the rate increases sharply at lower concentrations of surfactant until it reaches to a plateau in contrast to the appearance of maxima in case of CTAB and (CTA)2SO4.
Anionic surfactant, sodium dodecyl sulfate (SDS), inhibited the reaction rate at all concentrations used in the study.
Pseudophase ionexchange model was used for analyzing the effect of cationic micelles while the inhibition by SDS micelles was fitted using the Menger–Portnoy model.
The effect of salts (NaCl, NaBr and (CH3)4NBr) was also seen on the hydrolysis of indomethacin and it was found that all salts inhibited the rate of reaction.
The inhibition followed the trend NaCl < NaBr < (CH3) 4NBr.
American Psychological Association (APA)
al-Ayid, Abd Allah S.& Ali, Muhammad Sajid& al-Luhidan, Hamad A.& al-Sulayman, Adil M.& Isa, Zuhayr A.. 2014. Effect of reactive and non-reactive counterion micelles upon the alkaline degradation of indomethacin. Journal of Saudi Chemical Society،Vol. 18, no. 1, pp.77-83.
https://search.emarefa.net/detail/BIM-351516
Modern Language Association (MLA)
al-Ayid, Abd Allah S.…[et al.]. Effect of reactive and non-reactive counterion micelles upon the alkaline degradation of indomethacin. Journal of Saudi Chemical Society Vol. 18, no. 1 (Jan. 2014), pp.77-83.
https://search.emarefa.net/detail/BIM-351516
American Medical Association (AMA)
al-Ayid, Abd Allah S.& Ali, Muhammad Sajid& al-Luhidan, Hamad A.& al-Sulayman, Adil M.& Isa, Zuhayr A.. Effect of reactive and non-reactive counterion micelles upon the alkaline degradation of indomethacin. Journal of Saudi Chemical Society. 2014. Vol. 18, no. 1, pp.77-83.
https://search.emarefa.net/detail/BIM-351516
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 82-83
Record ID
BIM-351516