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Recent development in peptide coupling reagents
Joint Authors
al-Warhi, Tarafah I.
al-Hazimi, Hasan M. A.
al-Fahham, Aiman
Source
Journal of Saudi Chemical Society
Issue
Vol. 16, Issue 2 (30 Apr. 2012), pp.97-116, 20 p.
Publisher
Publication Date
2012-04-30
Country of Publication
Saudi Arabia
No. of Pages
20
Main Subjects
Topics
Abstract EN
Two decades of domination of benzotriazole-based chemistry stimulated the progress in peptide synthesis to a high level of effectiveness.
However, the growing need for new and more complex peptide structures, particularly for biomedical studies and, very recently, for the large-scale production of peptides as drugs, required manufacturing peptide products by efficient synthetic strategies, at reasonably low prices.
Therefore, the search for new, more versatile and low-cost reagents becomes a great challenge.
Several comprehensive review articles summarized the great effort undertaken, but up to now, no versatile coupling reagent useful for both amide and ester bond formation, as well as for solution and solid-phase peptide synthesis has been yet developed.
The most-widely used coupling reagents are carbodiimides on one hand and phosphonium and aminium salts on the other.
Herein in this review article, we summarized the recent development in peptide coupling reagents during the last two decades.
American Psychological Association (APA)
al-Warhi, Tarafah I.& al-Hazimi, Hasan M. A.& al-Fahham, Aiman. 2012. Recent development in peptide coupling reagents. Journal of Saudi Chemical Society،Vol. 16, no. 2, pp.97-116.
https://search.emarefa.net/detail/BIM-351687
Modern Language Association (MLA)
al-Warhi, Tarafah I.…[et al.]. Recent development in peptide coupling reagents. Journal of Saudi Chemical Society Vol. 16, no. 2 (Apr. 2012), pp.97-116.
https://search.emarefa.net/detail/BIM-351687
American Medical Association (AMA)
al-Warhi, Tarafah I.& al-Hazimi, Hasan M. A.& al-Fahham, Aiman. Recent development in peptide coupling reagents. Journal of Saudi Chemical Society. 2012. Vol. 16, no. 2, pp.97-116.
https://search.emarefa.net/detail/BIM-351687
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 113-116
Record ID
BIM-351687