Synthesis, characterization and antimicrobial activities of new bis-drazonothioxothiazolidinone derivatives

Abstract EN

New bis-hydrazonothioxothiazolidinone derivatives based on 2-thioxothiazolidin-4-one were synthesized in good yields using a simplified experimental condition.

The structure of synthesized compounds was established with the help of common physico-chemical analysis and various spectroscopic techniques like FT-IR, mass and 1H NMR.

The results of characterizations are in good agreement with the proposed structure of all the synthesized compounds.

Further, the antimicrobial (antibacterial and antifungal) activities of all the synthesized derivatives were carried out against various species like Bacillus subtilis, Escherichia coli, Aspergillous niger and Aspergillous flavus by using agar-cup method.

The results of antimicrobial screening showed that all the compounds have mild to moderate activity.

However, some of the compounds (3a, 3b, 3d, 3e, 3f, 3g, 3i and 3j) have shown better activity than the other.