Microwave synthesis, characterization and antimicrobial study of new pyrazolyl-oxopropyl-quinazolin-4 (3H)‎-one derivatives

Abstract EN

Heterocyclic compounds containing pyrazolyl-oxopropyl-quinazolin-4 (3H)-one are reported to possess significant biological activity.

Syntheses of 6-bromo-2-(3-chloro-2-oxopropyl)-3-(4-fluorophenyl) quinazolin-4(3H)-one 2 6-bromo-3-(4-fluorophenyl)-2-(3-hydrazinyl-2-oxopropyl)qui nazolin- 4 (3H)-one 3 and 6-bromo-2-(3-(3-(4-(1-(2-chlorophenyl)-3-methyl-1H-pyrazol-5(4H)-ylideneamino) phenyl)-5-(substituted phenyl)-4, 5-dihydro-1H-pyrazol-1-yl)-2-oxopropyl)-3-(4-fluorophenyl)quinazolin- 4(3H)-one 5a–j using microwave irradiation have been described.

These compounds have been characterized on the basis of theUV, IR, 1HNMR, 13CNMR,Mass and elemental analysis.Compounds have been evaluated for their antimicrobial activity.