Synthesis and in-vitro-antibacterial activity of [5-(furan-2-yl)-phenyl]-4, 5-carbothioamide-pyrazolines
Joint Authors
Yusuf, Muhammad
Rani, Mamta
Khan, Salman Ahmad
Source
Journal of Saudi Chemical Society
Issue
Vol. 16, Issue 4 (31 Oct. 2012), pp.431-436, 6 p.
Publisher
Publication Date
2012-10-31
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Topics
Abstract EN
Cyclization of various different alkoxy [1-[2-(alkoxy)phenyl]-5-(furan-2-yl)-prop-2-en- 1-one] chalcone with thiosemicarbazide in the presence of NaOH in ethanol afforded a series of novel 1-N-substituted cyclized pyrazoline analogues [5-(furan-2-yl)-3-[2-(alkoxy) phenyl]-4,5-dihydro- 1H-pyrazole-1-carbothioamide 2a–2d.
The structures of these compounds were elucidated by IR, 1H NMR, 13C NMR, Fab mass spectrometry and their purities were confirmed by elemental analyses.
In vitro antibacterial activity of these compounds were evaluated by the disk diffusion assay and then the minimum inhibitory concentration (MIC) strain of two Gram-positive and two Gram-negative bacteria like Aeromonas hydrophila, Yersinia enterocolitica, Listeria monocytogenes, and Staphylococcus aureus, among all the compounds, alkoxy [5-(furan-2-yl)-2- (benzyloxy)phenyl]-4,5-dihydro-1H-pyrazole-1-carbothioamide 2b and 5-(furan-2-yl)-1-[2-(naphthalen- 2-ylmethoxy) phenyl]-4,5-dihydro-1H-pyrazole-1-carbothioamide 2d showed the most promising antibacterial agent when compared to gentamicin and tetracycline.
American Psychological Association (APA)
Rani, Mamta& Yusuf, Muhammad& Khan, Salman Ahmad. 2012. Synthesis and in-vitro-antibacterial activity of [5-(furan-2-yl)-phenyl]-4, 5-carbothioamide-pyrazolines. Journal of Saudi Chemical Society،Vol. 16, no. 4, pp.431-436.
https://search.emarefa.net/detail/BIM-351786
Modern Language Association (MLA)
Rani, Mamta…[et al.]. Synthesis and in-vitro-antibacterial activity of [5-(furan-2-yl)-phenyl]-4, 5-carbothioamide-pyrazolines. Journal of Saudi Chemical Society Vol. 16, no. 4 (Oct. 2012), pp.431-436.
https://search.emarefa.net/detail/BIM-351786
American Medical Association (AMA)
Rani, Mamta& Yusuf, Muhammad& Khan, Salman Ahmad. Synthesis and in-vitro-antibacterial activity of [5-(furan-2-yl)-phenyl]-4, 5-carbothioamide-pyrazolines. Journal of Saudi Chemical Society. 2012. Vol. 16, no. 4, pp.431-436.
https://search.emarefa.net/detail/BIM-351786
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 436
Record ID
BIM-351786