Study of michael addition on chalcones and or chalcone analogues

Abstract EN

Michael addition reaction of 1,3-diphenyl-propenone 1a, e, and f with o-amino thiophenol in the presence of indium trichloride gave the benzothiazine derivatives 2a-c.

Condensation of the compound 1a, e with o-phenylene diamine in triethylamine gave the benzodiazepine derivatives 3a-b.

Cyclization of 1d with malononitrile in the presence of NaOR / EtOH gave the compound 4.

Addition of thiobarbituric acid in triethylamin to 1a gave 5.

Condensation of compound 1c with malononitrile in the presence ammonium acetate gave compound 6.

1,3-diphenyl-propenone 1a used as key starting chalcone to react with different active methylene reagents under phase-transfer catalysis condition gave compound 7-9.

The structures of the prepared compounds were mainly confirmed on the basis of spectroscopic methods.