Synthesis and biological evaluation of new oxime-ether derivatives of steroid as anti-bacterial agents
Joint Authors
Asiri, Abd Allah Muhammad
Khan, Salman A.
Salim, Kishwar
Source
Journal of Saudi Chemical Society
Issue
Vol. 16, Issue 1 (31 Jan. 2012), pp.7-11, 5 p.
Publisher
Publication Date
2012-01-31
Country of Publication
Saudi Arabia
No. of Pages
5
Main Subjects
Topics
Abstract EN
Various oxime-ether derivatives of cholesterol have been synthesized by the alkylation of the steroidal oxime with 1-(2-chloroethyl) pyrrolidine hydrogen chloride/chloroethylamine hydrochloride in the presence of sodium methoxide in dry methanol.
The structures of these compounds were elucidated by IR 1H NMR, FAB mass spectroscopic methods and elemental analyses.
The anti-bacterial activity was first tested in vitro by the disk diffusion method against two Gram-positive and two Gram-negative bacteria, and then the minimum inhibitory concentration (MIC) of compounds were determined.
The results showed that the chloro derivatives exhibited better anti-bacterial activity than the standard drug chloramphenicol.
American Psychological Association (APA)
Khan, Salman A.& Asiri, Abd Allah Muhammad& Salim, Kishwar. 2012. Synthesis and biological evaluation of new oxime-ether derivatives of steroid as anti-bacterial agents. Journal of Saudi Chemical Society،Vol. 16, no. 1, pp.7-11.
https://search.emarefa.net/detail/BIM-351978
Modern Language Association (MLA)
Khan, Salman A.…[et al.]. Synthesis and biological evaluation of new oxime-ether derivatives of steroid as anti-bacterial agents. Journal of Saudi Chemical Society Vol. 16, no. 1 (Jan. 2012), pp.7-11.
https://search.emarefa.net/detail/BIM-351978
American Medical Association (AMA)
Khan, Salman A.& Asiri, Abd Allah Muhammad& Salim, Kishwar. Synthesis and biological evaluation of new oxime-ether derivatives of steroid as anti-bacterial agents. Journal of Saudi Chemical Society. 2012. Vol. 16, no. 1, pp.7-11.
https://search.emarefa.net/detail/BIM-351978
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 11
Record ID
BIM-351978