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Synthesis, characterization, antifungal, antibacterial and DNA cleavage studies of some heterocyclic Schiff base metal complexes
Joint Authors
Nair, Madhavan Sivasankaran
Arish, Dasan
Joseyphus, Rafail Silwin
Source
Journal of Saudi Chemical Society
Issue
Vol. 16, Issue 1 (31 Jan. 2012), pp.83-88, 6 p.
Publisher
Publication Date
2012-01-31
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Topics
Abstract EN
Co (II), Ni (II), Cu (II) and Zn (II) complexes of the Schiff base derived from indole-3-carboxaldehyde and m-aminobenzoic acid were synthesized and characterized by elemental analysis, molar conductance, IR, UV-Vis, magnetic moment, powder XRD and SEM.
The IR results demonstrate the bidentate binding mode of the ligand involving azomethine nitrogen and carboxylate oxygen atoms.
The electronic spectral and magnetic moment results indicate that Co (II) and Ni (II) complexes have tetrahedral geometry, while Cu (II) complex is square planar.
Powder XRD and SEM indicate the crystalline state and surface morphology studies of the complexes.
The antimicrobial activity of the synthesized ligand and its complexes were screened by disc diffusion method.
The results show that the metal complexes were found to be more active than the ligand.
The nuclease activity of the ligand and its complexes were assayed on CT DNA using gel electrophoresis in the presence of H2O2.
The Cu (II) complex showed increased nuclease activity in the presence of an oxidant when compared to the ligand and other complexes.
American Psychological Association (APA)
Nair, Madhavan Sivasankaran& Arish, Dasan& Joseyphus, Rafail Silwin. 2012. Synthesis, characterization, antifungal, antibacterial and DNA cleavage studies of some heterocyclic Schiff base metal complexes. Journal of Saudi Chemical Society،Vol. 16, no. 1, pp.83-88.
https://search.emarefa.net/detail/BIM-352034
Modern Language Association (MLA)
Nair, Madhavan Sivasankaran…[et al.]. Synthesis, characterization, antifungal, antibacterial and DNA cleavage studies of some heterocyclic Schiff base metal complexes. Journal of Saudi Chemical Society Vol. 16, no. 1 (Jan. 2012), pp.83-88.
https://search.emarefa.net/detail/BIM-352034
American Medical Association (AMA)
Nair, Madhavan Sivasankaran& Arish, Dasan& Joseyphus, Rafail Silwin. Synthesis, characterization, antifungal, antibacterial and DNA cleavage studies of some heterocyclic Schiff base metal complexes. Journal of Saudi Chemical Society. 2012. Vol. 16, no. 1, pp.83-88.
https://search.emarefa.net/detail/BIM-352034
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 88
Record ID
BIM-352034