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Some new quinazolin-4 (3H)-one derivatives, synthesis and antitumor activity
Author
Source
Journal of Saudi Chemical Society
Issue
Vol. 15, Issue 4 (31 Oct. 2011), pp.337-343, 7 p.
Publisher
Publication Date
2011-10-31
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Abstract EN
A series of some new 2,3-disubstituted-6-iodo-3H-quinazolin-4-one derivatives was prepared and screened for their in vitro antitumor activity against the human breast cancer cell line (MCF-7), human cervix carcinoma cell line (HeLa), human liver cancer cell line (HepG2) and human colon cancer cell line HCT-8.
Five compounds exhibited broad spectrum antitumor activity, better than the standard drug Doxorubicin (CAS-23214-92-8) against the four tested cell lines.
In the present study, MCF-7 cell line was the most sensitive one, 12 compounds were good cytotoxic towards it.
The best cytotoxic results were obtained with compounds bearing allyl and/or benzyl moiety at positions 2 and/or 3 of the quinazoline nucleus.
American Psychological Association (APA)
al-Affafi, Ahmad Mahmud. 2011. Some new quinazolin-4 (3H)-one derivatives, synthesis and antitumor activity. Journal of Saudi Chemical Society،Vol. 15, no. 4, pp.337-343.
https://search.emarefa.net/detail/BIM-352087
Modern Language Association (MLA)
al-Affafi, Ahmad Mahmud. Some new quinazolin-4 (3H)-one derivatives, synthesis and antitumor activity. Journal of Saudi Chemical Society Vol. 15, no. 4 (Oct. 2011), pp.337-343.
https://search.emarefa.net/detail/BIM-352087
American Medical Association (AMA)
al-Affafi, Ahmad Mahmud. Some new quinazolin-4 (3H)-one derivatives, synthesis and antitumor activity. Journal of Saudi Chemical Society. 2011. Vol. 15, no. 4, pp.337-343.
https://search.emarefa.net/detail/BIM-352087
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 342-343
Record ID
BIM-352087